Compared with traditional de novo drug discovery, drug repurposing has become an
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …

Fungal organisms are ubiquitous in nature, and progress of modern medicine is creating an
expanding number of severely compromised patients susceptible to a variety of …

The blood-brain barrier (BBB) protects the central nervous system (CNS) by restricting the
passage of molecules and microorganisms. Despite this barrier, however, the fungal …

Mass spectrometry (MS) is a powerful technique that can provide the biochemical signature
of a wide range of biological materials such as cells and biofluids. However, MS data usually …

Many infectious diseases disproportionately affect people in the developing world.
Cryptococcal meningitis is one of the most common mycoses in HIV-AIDS patients, with the …

Bacterial efflux pumps transport small molecules from the cytoplasm or periplasm outside
the cell. Efflux pump activity is typically increased in multi-drug resistant (MDR) pathogens; …

As the diagnosis of cryptococcosis is challenging in low‐prevalence settings, uncovering
predictive factors can improve early diagnosis and timely treatment. The aim of the study …

Variable selection with supervised classification is currently an important tool for
discriminating biological samples. In this paper, 15 supervised classification algorithms …

Cryptococcal meningitis (CM) is associated with high morbidity and mortality. Current
antifungal drug therapy for CM has the following challenges: limited efficacy, significant side …

Cryptococcus neoformans is a pathogen that is common in immunosuppressed patients. It
can be treated with amphotericin B and fluconazole, but the mortality rate remains 15 to …