Proton‐pump inhibitor failure has become a common clinical dilemma in gastrointestinal
clinics and has been increasingly encountered at the primary care level as well. Underlying …

Gastroesophageal reflux disease (GERD) is a condition that develops when the reflux of
gastric contents into the esophagus leads to troublesome symptoms and/or complications …

Aliment Pharmacol Ther 2011; 34: 476–486 Summary Background Limited data are
available regarding the frequency of oesophageal motility and bolus transit abnormalities in …

Background Impedance‐pH monitoring allows assessment of retrograde and antegrade
intra‐esophageal movement of fluids and gas. Reflux is followed by volume clearance and …

BACKGROUND Histology is generally considered as a tool of limited value in the diagnosis
of gastro-esophageal reflux disease (GERD). AIM To reevaluate the diagnostic role of …

Esophageal motility abnormalities are among the main factors implicated in the
pathogenesis of gastroesophageal reflux disease. The recent introduction in clinical and …

BACKGROUND AND AIMS: Multichannel intraluminal impedance combined with pH-metry
is a novel technique for studying gastro-oesophageal reflux. As refluxes are particularly …

Background Hiatal hernia is diagnosed by barium-swallow esophagogram or
esophagogastroduodenoscopy, with possible suboptimal results. High-resolution …

Proton-pump inhibitor (PPI) failure in gastro-oesophageal reflux disease (GORD) patients
has become the main reason for referral of these patients to gastroenterology specialists. It …

Heartburn is a common symptom in clinical practice, but as many as 70% of patients have
normal findings from upper endoscopy. Most of these patients have nonerosive reflux …