[HTML][HTML] Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

[HTML][HTML] Mitochondrial dysfunction plays central role in nonalcoholic fatty liver disease

R Ramanathan, AH Ali, JA Ibdah - International Journal of Molecular …, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is a global pandemic that affects one-quarter of the
world's population. NAFLD includes a spectrum of progressive liver disease from steatosis to …

Emerging role of aging in the progression of NAFLD to HCC

Y He, Y Su, C Duan, S Wang, W He, Y Zhang… - Ageing Research …, 2023 - Elsevier
With the aging of global population, the incidence of nonalcoholic fatty liver disease
(NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a …

[HTML][HTML] Hydroxytyrosol promotes the mitochondrial function through activating mitophagy

Y Dong, M Yu, Y Wu, T Xia, L Wang, K Song, C Zhang… - Antioxidants, 2022 - mdpi.com
Emerging evidence suggests that mitochondrial dysfunction mediates the pathogenesis for
non-alcoholic fatty liver disease (NAFLD). Hydroxytyrosol (HT) is a key component of extra …

[HTML][HTML] Lipid and glucose metabolism in senescence

B Liu, Q Meng, X Gao, H Sun, Z Xu, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Senescence is an inevitable biological process. Disturbances in glucose and lipid
metabolism are essential features of cellular senescence. Given the important roles of these …

Autophagy and the unfolded protein response shape the non-alcoholic fatty liver landscape: decoding the labyrinth

Z Dashti, Z Yousefi, P Kiani, M Taghizadeh, MH Maleki… - Metabolism, 2024 - Elsevier
The incidence of nonalcoholic fatty liver disease (NAFLD) is on the rise, mirroring a global
surge in diabetes and metabolic syndrome, as its major leading causes. NAFLD represents …

Cell senescence in liver diseases: pathological mechanism and theranostic opportunity

D Sanfeliu-Redondo, A Gibert-Ramos… - Nature Reviews …, 2024 - nature.com
The liver is not oblivious to the passage of time, as ageing is a major risk factor for the
development of acute and chronic liver diseases. Ageing produces alterations in all hepatic …

[HTML][HTML] Non-Alcoholic Fatty Liver Disease Is Associated with a Decreased Catalase (CAT) Level, CT Genotypes and the T Allele of the -262 C/T CAT Polymorphism

M Kosmalski, I Szymczak-Pajor, J Drzewoski… - Cells, 2023 - mdpi.com
Background: It is well known that oxidative stress plays an important role in the development
of non-alcoholic fatty liver disease (NAFLD). It has been suggested that an insufficient …

Rab7a-mTORC1 signaling-mediated cholesterol trafficking from the lysosome to mitochondria ameliorates hepatic lipotoxicity induced by aflatoxin B1 exposure

JX Lin, CY Xu, XM Wu, L Che, TY Li, SM Mo, DB Guo… - Chemosphere, 2023 - Elsevier
Abstract Aflatoxin B1 (AFB1) is a common contaminant in many foodstuffs and is considered
a public health concern worldwide due to its hepatotoxicity caused by lipid metabolism …

[HTML][HTML] New Insights into Antioxidant Peptides: An Overview of Efficient Screening, Evaluation Models, Molecular Mechanisms, and Applications

Y Zhang, Y Li, Z Quan, P Xiao, JA Duan - Antioxidants, 2024 - mdpi.com
Antioxidant peptides are currently a hotspot in food science, pharmaceuticals, and
cosmetics. In different fields, the screening, activity evaluation, mechanisms, and …