Purpose: Antimicrobial stewardship programs are important for reducing antimicrobial
resistance because they can readjust antibiotic prescriptions to local guidelines, switch …

Despite their limitations, the pharmacokinetics (PK) and pharmacodynamics (PD) indices
form the basis for our current understanding regarding antibiotic development, selection …

Meropenem is one of the most frequently used antibiotics to treat life-threatening infections
in critically ill patients. This study aimed to develop a meropenem dosing algorithm for the …

Background Meropenem is commonly used in the ICU to treat gram-negative infections. Due
to various pathophysiological changes, critically ill patients are at higher risk of having …

The optimal method for administering meropenem remains controversial. This study was
conducted to explore the optimal two-step infusion strategy (TIT), and to investigate whether …

To describe the pharmacokinetics/pharmacodynamics (PK/PD) of a 2 h infusion of
ceftazidime‐avibactam (CAZ‐AVI) in critically ill patients with augmented renal clearance …

多重耐药革兰阴性菌感染的危重症患者, 因个体间药动学(PK) 参数差异较大,
接受说明书推荐给药剂量的3 内酰胺类抗菌药物治疗, 其药动学/药效学(pharmacodynamics …

Meropenem is a broad-spectrum carbapenem antibiotic which is commonly prescribed for
treatment of severe infections caused by multidrug-resistant bacteria [1]. In critically ill …

Meropenem is a broad-spectrum carbapenem antibiotic which is commonly prescribed for
treatment of severe infections caused by multidrug-resistant bacteria [1]. In critically ill …