Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently
discovered member of the opioid receptor family and, together with its endogenous ligand …

Background & Aims Maintenance of acid–base homeostasis is required for normal
physiology, metabolism, and development. It is not clear how cell death is activated in …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

The advance of functional genomics revealed the superfamily of G-protein coupled
receptors (GPCRs). Hundreds of GPCRs have been cloned but many of them are orphan …

Nociceptin-opioid peptide (NOP) receptor, also known as opioid receptor like-1 (ORL1), was
identified following the cloning of the kappa-opioid peptide (KOP) receptor, and the …

Background and Purpose Single‐prolonged stress (SPS), a rat model of post‐traumatic
stress disorder (PTSD), also induces long‐lasting hyperalgesia associated with …

Chemotherapy-induced peripheral neuropathy is a serious adverse effect of
chemotherapeutic agents such as paclitaxel. JTC-801, a nociceptin/orphanin FQ opioid …

Spinal cord injury (SCI) is a central nervous system injury that leads to neurological
dysfunction or paralysis, which seriously affects patients' quality of life and causes a heavy …

Central nociceptin/orphanin FQ (N/OFQ)‐expressing neurones are abundantly expressed in
the hypothalamus and limbic system and are implicated in the regulation of activity of the …