Natural killer cell homing and trafficking in tissues and tumors: from biology to application

GH Ran, YQ Lin, L Tian, T Zhang, DM Yan… - Signal transduction and …, 2022 - nature.com
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

Influence of the tumor microenvironment on NK cell function in solid tumors

O Melaiu, V Lucarini, L Cifaldi, D Fruci - Frontiers in immunology, 2020 - frontiersin.org
Natural killer (NK) cells are a population of innate lymphoid cells playing a pivotal role in
host immune responses against infection and tumor growth. These cells have a powerful …

Targeting of the tumor immune microenvironment by metformin

Z Wu, C Zhang, M Najafi - Journal of cell communication and signaling, 2022 - Springer
Stimulating antitumor immunity is an attractive idea for suppressing tumors. CD4+ and CD8+
T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor …

Harnessing CD16-mediated NK cell functions to enhance therapeutic efficacy of tumor-targeting mAbs

C Capuano, C Pighi, S Battella, D De Federicis… - Cancers, 2021 - mdpi.com
Simple Summary Natural Killer (NK) cells play a major role in cancer immunotherapy based
on tumor-targeting mAbs. NK cell-mediated tumor cell killing and cytokine secretion are …

[HTML][HTML] EpCAM-high liver cancer stem cells resist natural killer cell–mediated cytotoxicity by upregulating CEACAM1

DJ Park, PS Sung, JH Kim, GW Lee… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Natural killer (NK) cells can recognize and kill cancer cells directly, but their
activity can be attenuated by various inhibitory molecules expressed on the surface. The …

Natural killer cells: diverse functions in tumor immunity and defects in pre-neoplastic and neoplastic stages of tumorigenesis

A Jewett, J Kos, K Kaur, T Safaei, C Sutanto… - Molecular Therapy …, 2020 - cell.com
Natural killer (NK) cells are the key immune effectors with the ability to mediate selection and
differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and …

[HTML][HTML] Click chemistry and drug delivery: A bird's-eye view

SM Kondengadan, S Bansal, C Yang, D Liu… - … Pharmaceutica Sinica B, 2023 - Elsevier
Click chemistry has been proven to be very useful in drug delivery. Due to the availability of
a large number of click reactions with a various characteristics, selection of appropriate …

[HTML][HTML] The adverse impact of tumor microenvironment on NK-cell

Z Hu, X Xu, H Wei - Frontiers in Immunology, 2021 - frontiersin.org
NK cells are considered an important component of innate immunity, which is the first line of
defensing against tumors and viral infections in the absence of prior sensitization. NK cells …

NK cells shape pancreatic and oral tumor microenvironments; role in inhibition of tumor growth and metastasis

A Jewett, J Kos, Y Fong, MW Ko, T Safaei… - Seminars in cancer …, 2018 - Elsevier
We have recently shown that natural killer (NK) cells select and differentiate cancer stem
cells (CSCs)/undifferentiated tumors via secreted and membrane bound IFN-gamma (IFN-γ) …

Probiotic-treated super-charged NK cells efficiently clear poorly differentiated pancreatic tumors in Hu-BLT mice

K Kaur, AK Kozlowska, P Topchyan, MW Ko… - Cancers, 2019 - mdpi.com
Background and Aims: We have previously demonstrated that the stage of differentiation of
tumors has profound effect on the function of NK cells, and that stem-like/poorly …