Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics

M Adamaki, V Zoumpourlis - Pharmacology & therapeutics, 2021 - Elsevier
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies and among the
leading causes of cancer-related death worldwide. It is a highly heterogeneous disease …

Targeting PI3K/Akt signaling in prostate cancer therapy

M Hashemi, A Taheriazam, P Daneii… - Journal of Cell …, 2023 - Springer
Urological cancers have obtained much attention in recent years due to their mortality and
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …

Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling

H Lu, H Xiao, M Dai, Y Xue, R Zhao - Pharmaceutical Biology, 2022 - Taylor & Francis
Context Ferroptosis was described as an important contributor to the myocardial
ischaemia/reperfusion (MIR) injury, and britanin (Bri) was reported to exert antitumor and …

[HTML][HTML] Molecular basis of prostate cancer and natural products as potential chemotherapeutic and chemopreventive agents

B Bai, Q Chen, R Jing, X He, H Wang, Y Ban… - Frontiers in …, 2021 - frontiersin.org
Prostate cancer is the second most common malignant cancer in males. It involves a
complex process driven by diverse molecular pathways that closely related to the survival …

Study on inhibition of Britannin on triple-negative breast carcinoma through degrading ZEB1 proteins

H Lu, Z Wu, Y Wang, D Zhao, B Zhang, M Hong - Phytomedicine, 2022 - Elsevier
Background Triple-negative breast carcinomas (TNBCs) are a breast carcinoma with the
most aggressive form, which is demonstrated as enhanced invasion and recurrence …

Sesquiterpene lactones as emerging biomolecules to cease cancer by targeting apoptosis

CY Hsu, S Rajabi, M Hamzeloo-Moghadam… - Frontiers in …, 2024 - frontiersin.org
Apoptosis is a programmed cell death comprising two signaling cascades including the
intrinsic and extrinsic pathways. This process has been shown to be involved in the therapy …

[HTML][HTML] Britanin–a beacon of hope against gastrointestinal tumors?

A Kajdanek, D Kołat, LY Zhao, M Kciuk… - World Journal of …, 2024 - ncbi.nlm.nih.gov
Britanin is a bioactive sesquiterpene lactone known for its potent anti-inflammatory and anti-
oxidant properties. It also exhibits significant anti-tumor activity, suppressing tumor growth in …

Britanin inhibits titanium wear particle‑induced osteolysis and osteoclastogenesis

JA Kim, S Lim, HJ Ihn, JE Kim… - Molecular …, 2023 - spandidos-publications.com
Wear particle‑induced osteolysis is a serious complication that occurs in individuals with
titanium (Ti)‑based implants following long‑term usage due to loosening of the implants. The …

Based on Network Pharmacology‐Quercetin, a Component of Fuzheng Yiliu Decoction Suppressed Prostate Cancer by Regulating PI3K/AKT Pathway

W Fu, L Xu, Y Chen, X Lin, G Hao, C Li, H Li… - Andrologia, 2023 - Wiley Online Library
Background. Fuzheng Yiliu decoction (FZYLD) was a traditional prescription with an
antitumor effect. We aimed to explore the antitumor effect of FZYLD and its active ingredient …

Plantamajoside Inhibits the Growth of Acute Myeloid Leukemia Cells by Modulating NF-κB and PI3K/AKT Signaling Pathways.

X Zhou, G Wang, Q Wu, M Yang - Current Topics in …, 2022 - search.ebscohost.com
Acute myeloid leukemia is a highly invasive and heterogeneous malignant tumor.
Plantamajoside, a natural compound extracted from Plantago asiatica L., has been shown to …