[HTML][HTML] Concepts in oncolytic adenovirus therapy

K Mantwill, FG Klein, D Wang, SV Hindupur… - International Journal of …, 2021 - mdpi.com
Oncolytic adenovirus therapy is gaining importance as a novel treatment option for the
management of various cancers. Different concepts of modification within the adenovirus …

[HTML][HTML] Protein phase separation and its role in tumorigenesis

S Jiang, JB Fagman, C Chen, S Alberti, B Liu - Elife, 2020 - elifesciences.org
Cancer is a disease characterized by uncontrolled cell proliferation, but the precise
pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent …

[HTML][HTML] CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1

J Xu, L Ji, Y Liang, Z Wan, W Zheng, X Song… - Signal transduction and …, 2020 - nature.com
Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma
(HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and the …

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes

MJ Shurtleff, J Yao, Y Qin… - Proceedings of the …, 2017 - National Acad Sciences
RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA
composition of EVs is challenging due to their coisolation with contaminants, lack of …

YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1

SP Somasekharan, A El-Naggar, G Leprivier… - Journal of Cell …, 2015 - rupress.org
Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is
to sequester and silence mRNAs in ribonucleoprotein complexes known as stress granules …

YB‐1 protein: functions and regulation

DN Lyabin, IA Eliseeva… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
The Y‐box binding protein 1 (YB‐1, YBX1) is a member of the family of DNA‐and RNA‐
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …

Long noncoding RNA HULC modulates the phosphorylation of YB‐1 through serving as a scaffold of extracellular signal–regulated kinase and YB‐1 to enhance …

D Li, X Liu, J Zhou, J Hu, D Zhang, J Liu, Y Qiao… - …, 2017 - Wiley Online Library
Dysregulated expression of long noncoding RNAs has been reported in many types of
cancers, indicating that it may play a critical role in tumorigenesis. The long noncoding RNA …

Silencing of Long Noncoding RNA MIR22HG Triggers Cell Survival/Death Signaling via Oncogenes YBX1, MET, and p21 in Lung Cancer

W Su, S Feng, X Chen, X Yang, R Mao, C Guo, Z Wang… - Cancer research, 2018 - AACR
The long noncoding RNA (lncRNA) MIR22HG has previously been identified as a prognostic
marker in hepatocellular carcinoma. Here, we performed a comprehensive analysis of …

[HTML][HTML] Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells

S Khozooei, K Lettau, F Barletta, T Jost… - Journal of Experimental …, 2022 - Springer
Background Triple-negative breast cancer (TNBC) is associated with aggressiveness and a
poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for …

[HTML][HTML] Y-box binding proteins in mRNP assembly, translation, and stability control

D Mordovkina, DN Lyabin, EA Smolin, EM Sogorina… - Biomolecules, 2020 - mdpi.com
Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large
family of proteins with the cold shock domain. Functionally, these proteins are known to be …