[HTML][HTML] Concepts in oncolytic adenovirus therapy
K Mantwill, FG Klein, D Wang, SV Hindupur… - International Journal of …, 2021 - mdpi.com
Oncolytic adenovirus therapy is gaining importance as a novel treatment option for the
management of various cancers. Different concepts of modification within the adenovirus …
management of various cancers. Different concepts of modification within the adenovirus …
[HTML][HTML] Protein phase separation and its role in tumorigenesis
Cancer is a disease characterized by uncontrolled cell proliferation, but the precise
pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent …
pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent …
[HTML][HTML] CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1
Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma
(HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and the …
(HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and the …
Broad role for YBX1 in defining the small noncoding RNA composition of exosomes
RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA
composition of EVs is challenging due to their coisolation with contaminants, lack of …
composition of EVs is challenging due to their coisolation with contaminants, lack of …
YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1
SP Somasekharan, A El-Naggar, G Leprivier… - Journal of Cell …, 2015 - rupress.org
Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is
to sequester and silence mRNAs in ribonucleoprotein complexes known as stress granules …
to sequester and silence mRNAs in ribonucleoprotein complexes known as stress granules …
YB‐1 protein: functions and regulation
DN Lyabin, IA Eliseeva… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
The Y‐box binding protein 1 (YB‐1, YBX1) is a member of the family of DNA‐and RNA‐
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …
Long noncoding RNA HULC modulates the phosphorylation of YB‐1 through serving as a scaffold of extracellular signal–regulated kinase and YB‐1 to enhance …
D Li, X Liu, J Zhou, J Hu, D Zhang, J Liu, Y Qiao… - …, 2017 - Wiley Online Library
Dysregulated expression of long noncoding RNAs has been reported in many types of
cancers, indicating that it may play a critical role in tumorigenesis. The long noncoding RNA …
cancers, indicating that it may play a critical role in tumorigenesis. The long noncoding RNA …
Silencing of Long Noncoding RNA MIR22HG Triggers Cell Survival/Death Signaling via Oncogenes YBX1, MET, and p21 in Lung Cancer
W Su, S Feng, X Chen, X Yang, R Mao, C Guo, Z Wang… - Cancer research, 2018 - AACR
The long noncoding RNA (lncRNA) MIR22HG has previously been identified as a prognostic
marker in hepatocellular carcinoma. Here, we performed a comprehensive analysis of …
marker in hepatocellular carcinoma. Here, we performed a comprehensive analysis of …
[HTML][HTML] Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells
S Khozooei, K Lettau, F Barletta, T Jost… - Journal of Experimental …, 2022 - Springer
Background Triple-negative breast cancer (TNBC) is associated with aggressiveness and a
poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for …
poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for …
[HTML][HTML] Y-box binding proteins in mRNP assembly, translation, and stability control
D Mordovkina, DN Lyabin, EA Smolin, EM Sogorina… - Biomolecules, 2020 - mdpi.com
Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large
family of proteins with the cold shock domain. Functionally, these proteins are known to be …
family of proteins with the cold shock domain. Functionally, these proteins are known to be …