Here, we described a novel regulatory feedback loop in which hypoxia induces integrin-
linked kinase (ILK) expression through a HIF-1α-dependent mechanism and ILK, in turn …

Background Epithelial–mesenchymal transition (EMT) is a major actor modulating the
metastasis of nasopharyngeal carcinoma (NPC). Increasing evidence indicates that …

The Y‐box‐binding protein (YB)‐1 plays a non‐redundant role in both systemic and local
inflammatory response. We analysed YB‐1‐mediated expression of the immune regulatory …

Abstract Uncaria tomentosa (Willd.) DC.(Rubiacee), also known as uña de gato, is a plant
that grows wild in the upper Amazon region of Peru and has been widely used in folk …

Breast cancer is the principal cancer in women worldwide. Although there are serum tumor
markers such as CEA and HER2, they are detected in advanced stages of the disease and …

Gastric cancer (GC) has significant morbidity and mortality worldwide and especially in
China. Its molecular pathogenesis has not been thoroughly elaborated. The acknowledged …

Pancreatic cancer is one of the most aggressive cancers. The vast majority of patients are
diagnosed with advanced, unresectable disease because of early invasive growth and …

Ionizing radiation (IR) and epidermal growth factor (EGF) stimulate Y-box binding protein-1
(YB-1) phosphorylation at Ser-102 in KRAS wild-type (KRASwt) cells, whereas in KRAS …

Cold shock proteins (CSPs) are an ancient and conserved family of proteins. They are
renowned for their role in response to low-temperature stress in bacteria and nucleic acid …

Epithelial to mesenchymal transition (EMT) induces cell plasticity and promotes metastasis.
The multifunctional oncoprotein Y-box binding protein-1 (YB-1) and the pleiotropic cytokine …