A guide to antigen processing and presentation
Antigen processing and presentation are the cornerstones of adaptive immunity. B cells
cannot generate high-affinity antibodies without T cell help. CD4+ T cells, which provide …
cannot generate high-affinity antibodies without T cell help. CD4+ T cells, which provide …
The genetics of human ageing
The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …
Sustaining longer lives with reduced periods of disability will require an understanding of the …
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies
D Reichart, EL Lindberg, H Maatz, AMA Miranda… - Science, 2022 - science.org
Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic
cardiomyopathy (ACM) convey high risks for the development of heart failure through …
cardiomyopathy (ACM) convey high risks for the development of heart failure through …
The MHC locus and genetic susceptibility to autoimmune and infectious diseases
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
HLA variation and antigen presentation in COVID-19 and SARS-CoV-2 infection
DG Augusto, JA Hollenbach - Current opinion in immunology, 2022 - Elsevier
Highlights•Variation in both HLA and SARS-CoV-2 impact antigen presentation to T
cells.•HLA variation influences COVID-19 outcomes and T-cell responses to SARS-CoV …
cells.•HLA variation influences COVID-19 outcomes and T-cell responses to SARS-CoV …
The influence of HLA genotype on the severity of COVID‐19 infection
The impact of COVID‐19 varies markedly, not only between individual patients but also
between different populations. We hypothesised that differences in HLA genes might …
between different populations. We hypothesised that differences in HLA genes might …
Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals
Abstract The Tohoku Medical Megabank Organization reports the whole-genome
sequences of 1,070 healthy Japanese individuals and construction of a Japanese …
sequences of 1,070 healthy Japanese individuals and construction of a Japanese …
Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis
Abstract RNA-sequencing (RNA-seq) is an essential technique for transcriptome studies,
hundreds of analysis tools have been developed since it was debuted. Although recent …
hundreds of analysis tools have been developed since it was debuted. Although recent …
ODGI: understanding pangenome graphs
Motivation Pangenome graphs provide a complete representation of the mutual alignment of
collections of genomes. These models offer the opportunity to study the entire genomic …
collections of genomes. These models offer the opportunity to study the entire genomic …
Stem cell therapies for treating diabetes: progress and remaining challenges
Restoration of insulin independence and normoglycemia has been the overarching goal in
diabetes research and therapy. While whole-organ and islet transplantation have become …
diabetes research and therapy. While whole-organ and islet transplantation have become …