Morpholine is a versatile moiety, a privileged pharmacophore and an outstanding
heterocyclic motif with wide ranges of pharmacological activities due to different …

Because of a preconceived notion that eliminating reactive metabolite (RM) formation with
new drug candidates could mitigate the risk of idiosyncratic drug toxicity, the potential for RM …

The widespread use of antibiotics has made the problem of bacterial resistance increasingly
serious, and the study of new drug-resistant bacteria has become the main direction of …

Staphylococcus aureus bacteraemia is one of the most common serious bacterial infections
worldwide. In the UK alone, around 12 500 cases each year are reported, with an …

Linezolid was provided for treatment of multidrug-resistant, gram-positive infections through
a compassionate-use program. Patients (n= 796) received 600 mg of linezolid intravenously …

Skin and soft tissue infections (SSTIs) are a common cause of morbidity in both the
community and the hospital. An SSTI is classified as complicated if the infection has spread …

Objective: To characterise the pharmacokinetic-pharmacodynamic relationships for linezolid
efficacy. Design and study population: Retrospective nonblinded analysis of severely …

The average weight of adults in the U nited S tates has increased by 25 pounds (11 kg) over
the past 50 years, with a marginal change in height. Drugs are generally dosed according to …

Linezolid is the first antibacterial to be approved from the oxazolidinone class. The drug has
substantial antimicrobial activity against Gram-positive organisms such as streptococci …

The pharmacokinetics and pharmacodynamics of linezolid have been extensively
investigated in laboratory models, healthy volunteers and patients. Three formulations exist …