Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

Objective Emerging pathological evidence suggests that there is an association between
glymphatic dysfunction and the progression of Parkinson's disease (PD). However, the …

Abstract Purpose of Review Sleep disturbances are an important nonmotor feature of
Parkinson's disease (PD) that can cause polysomnographic (PSG) alterations. These …

IMPORTANCE Nonmotor symptoms of Parkinson disease (PD) often predate the movement
disorder by decades. Currently, there is no blood biomarker to define this prodromal phase …

Objectives Rapid eye movement sleep behavior disorder (RBD) is a potentially harmful,
often overlooked sleep disorder affecting up to 70% of Parkinson's disease patients. Current …

Although rapid eye movement (REM) sleep behavior disorder (RBD) has been widely
considered as a male-predominant parasomnia, the existing evidence for the sex difference …

Objective measures of disease progression are critically needed in research on Parkinson's
disease (PD) and atypical Parkinsonism but may be hindered by both practicality and cost …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by a range of motor
and non-motor symptoms. Among the motor complaints, freezing of gait (FOG) is a common …

Objectives To analyze REM sleep without atonia (RWA) metrics in patients with isolated
REM sleep behavior disorder (iRBD), Parkinson's disease (PD) and healthy subjects and …

Background Clinical presentation and progression dynamics are variable in patients with
Parkinson's disease (PD). Disease course mapping is an innovative disease modelling …