SARS-CoV-2 started spreading toward the end of 2019 causing COVID-19, a disease that
reached pandemic proportions among the human population within months. The reasons for …

Epithelial tissues protecting organs from the environment are the first-line of defense against
pathogens. Therefore, efficient repair mechanisms after injury are crucial to maintain …

Accurate and reliable measurements of exposure to tobacco products are essential for
identifying and confirming patterns of tobacco product use and for assessing their potential …

Rationale: The mechanisms underlying cystic fibrosis (CF) lung disease pathogenesis are
unknown. Objectives: To establish mechanisms linking anion transport with the functional …

A key aspect of the lung's innate defense system is the ability of the superficial epithelium to
regulate airway surface liquid (ASL) volume to maintain a 7-μm periciliary liquid layer (PCL) …

Exposed to a diverse array of potentially noxious agents, the respiratory tract is protected by
a highly developed innate defense system. Physiologically regulated epithelial ion and …

The mechanisms underlying the development and natural progression of the airway mucus
defect in cystic fibrosis (CF) remain largely unclear. New animal models of CF, coupled with …

The epithelial sodium channel (ENaC) represents the rate-limiting step of sodium absorption
across airway epithelia and thereby constitutes the major pathway for volume absorption …

Mucus secretion and mucociliary transport are essential defense mechanisms of the
airways. Deviations in mucus composition and secretion can impede mucociliary transport …

The Tmem16 gene family was first identified by bioinformatic analysis in 2004. In 2008, it
was shown independently by 3 laboratories that the first two members (Tmem16A and …