[HTML][HTML] Bone/cartilage targeted hydrogel: Strategies and applications

H Zhang, S Wu, W Chen, Y Hu, Z Geng, J Su - Bioactive materials, 2023 - Elsevier
The skeletal system is responsible for weight-bearing, organ protection, and movement.
Bone diseases caused by trauma, infection, and aging can seriously affect a patient's quality …

[HTML][HTML] Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions

Y Cho, S Jeong, H Kim, D Kang, J Lee… - … & molecular medicine, 2021 - nature.com
Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive
destruction of articular cartilage and the development of chronic pain and constitutes a …

[HTML][HTML] Chondrocyte ferroptosis contribute to the progression of osteoarthritis

X Yao, K Sun, S Yu, J Luo, J Guo, J Lin, G Wang… - Journal of orthopaedic …, 2021 - Elsevier
Background Osteoarthritis (OA) is a complex process comprised of mechanical load,
inflammation, and metabolic factors. It is still unknown that if chondrocytes undergo …

[HTML][HTML] Deferoxamine alleviates osteoarthritis by inhibiting chondrocyte ferroptosis and activating the Nrf2 pathway

Z Guo, J Lin, K Sun, J Guo, X Yao, G Wang… - Frontiers in …, 2022 - frontiersin.org
Objective: Osteoarthritis (OA) is a common disease with a complex pathology including
mechanical load, inflammation, and metabolic factors. Chondrocyte ferroptosis contributes to …

The non-coding RNA interactome in joint health and disease

SA Ali, MJ Peffers, MJ Ormseth, I Jurisica… - Nature Reviews …, 2021 - nature.com
Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …

Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes

X Wang, Z Liu, P Peng, Z Gong, J Huang… - Chemico-biological …, 2022 - Elsevier
Ferroptosis is a novel form of regulated cell death that has a close association with
mitochondrial dysfunction and is characterized by iron overload, the accumulation of …

[HTML][HTML] Small extracellular vesicles in combination with sleep-related circRNA3503: a targeted therapeutic agent with injectable thermosensitive hydrogel to prevent …

SC Tao, JY Huang, Y Gao, ZX Li, ZY Wei, H Dawes… - Bioactive materials, 2021 - Elsevier
Osteoarthritis (OA), characterized by chondrocyte apoptosis and disturbance of the balance
between catabolism and anabolism of the extracellular matrix (ECM), is the most common …

LncRNAs in osteoarthritis

HM Okuyan, MA Begen - Clinica Chimica Acta, 2022 - Elsevier
Osteoarthritis (OA) is a progressive joint disease that affects millions of older adults around
the world. With increasing rates of incidence and prevalence worldwide, OA has become an …

[HTML][HTML] The role of autophagy in gastric cancer chemoresistance: friend or foe?

JL Xu, L Yuan, YC Tang, ZY Xu, HD Xu… - Frontiers in Cell and …, 2020 - frontiersin.org
Gastric cancer is the third most common cause of cancer-related death worldwide. Drug
resistance is the main inevitable and vital factor leading to a low 5-year survival rate for …

Functional micro-RNA drugs acting as a fate manipulator in the regulation of osteoblastic death

Z Cai, F Liu, Y Li, L Bai, M Feng, S Li, W Ma, S Shi - Nanoscale, 2023 - pubs.rsc.org
Bone loss is prevalent in clinical pathological phenomena such as osteoporosis, which is
characterized by decreased osteoblast function and number, increased osteoclast activity …