Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

Chronic Venous Disease (CVD) refers to several pathological and hemodynamic alterations
of the veins of lower limbs causing a wide range of symptoms and signs with a high …

The endothelial glycocalyx encompasses the entire endothelial cell, transducing
extracellular signals and regulating vascular permeability and barrier functions. The apical …

The glycocalyx generally covers almost all cellular surfaces, where it participates in
mediating cell-surface interactions with the extracellular matrix as well as with intracellular …

Physical forces exert profound effects on cells affecting fate, function, and response to
stressors. In the case of the endothelium, the layer that resides in the inner surface of blood …

The brain endothelial cell (BEC) glycocalyx (ecGCx) is a BEC surface coating consisting of a
complex interwoven polysaccharide (sweet husk) mesh-like network of membrane-bound …

One question in lymphocyte homing is how integrins are rapidly activated to enable
immediate arrest of fast rolling lymphocytes upon encountering chemokines at target …

The disruption of endothelial heparan sulfate (HS) is an early event in tumor cell metastasis
across vascular barriers, and the reinforcement of endothelial HS reduces tumor cell …

Recent investigations analyzed in depth the biochemical and biophysical properties of the
endothelial glycocalyx. In comparison, this complex cell-covering structure is largely …

Cardiac surgery is one of the highest-risk procedures, usually involving cardiopulmonary
bypass and commonly inducing endothelial injury that contributes to the development of …