Vaccine adjuvants: mechanisms and platforms

T Zhao, Y Cai, Y Jiang, X He, Y Wei, Y Yu… - Signal transduction and …, 2023 - nature.com
Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …

Emerging concepts in the science of vaccine adjuvants

B Pulendran, P S. Arunachalam… - Nature Reviews Drug …, 2021 - nature.com
Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …

An overview of vaccine adjuvants: current evidence and future perspectives

A Facciolà, G Visalli, A Laganà, A Di Pietro - Vaccines, 2022 - mdpi.com
Vaccinations are one of the most important preventive tools against infectious diseases.
Over time, many different types of vaccines have been developed concerning the antigen …

Non-viral COVID-19 vaccine delivery systems

KS Park, X Sun, ME Aikins, JJ Moon - Advanced drug delivery reviews, 2021 - Elsevier
The novel corona virus termed severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has spread throughout the globe at a formidable speed, causing tens of millions of …

Delivery strategies for mRNA vaccines

S Ramachandran, SR Satapathy, T Dutta - Pharmaceutical medicine, 2022 - Springer
The therapeutic potential for messenger RNA (mRNA) in infectious diseases and cancer
was first realized almost three decades ago, but only in 2018 did the first lipid nanoparticle …

TREM2 macrophages induced by human lipids drive inflammation in acne lesions

TH Do, F Ma, PR Andrade, R Teles… - Science …, 2022 - science.org
Acne affects 1 in 10 people globally, often resulting in disfigurement. The disease involves
excess production of lipids, particularly squalene, increased growth of Cutibacterium acnes …

New-age vaccine adjuvants, their development, and future perspective

SK Verma, P Mahajan, NK Singh, A Gupta… - Frontiers in …, 2023 - frontiersin.org
In the present scenario, immunization is of utmost importance as it keeps us safe and
protects us from infectious agents. Despite the great success in the field of vaccinology …

[HTML][HTML] Vaccination in the elderly: the challenge of immune changes with aging

A Ciabattini, C Nardini, F Santoro, P Garagnani… - Seminars in …, 2018 - Elsevier
The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …

Lipid-based nanoparticles for delivery of vaccine adjuvants and antigens: toward multicomponent vaccines

D Chatzikleanthous, DT O'Hagan… - Molecular …, 2021 - ACS Publications
Despite the many advances that have occurred in the field of vaccine adjuvants, there are
still unmet needs that may enable the development of vaccines suitable for more …

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

HM Yassine, JC Boyington, PM McTamney, CJ Wei… - Nature medicine, 2015 - nature.com
The antibody response to influenza is primarily focused on the head region of the
hemagglutinin (HA) glycoprotein, which in turn undergoes antigenic drift, thus necessitating …