[HTML][HTML] The microbiota of the respiratory tract: gatekeeper to respiratory health

WH Man, WAA de Steenhuijsen Piters… - Nature Reviews …, 2017 - nature.com
The respiratory tract is a complex organ system that is responsible for the exchange of
oxygen and carbon dioxide. The human respiratory tract spans from the nostrils to the lung …

Dysbiosis of the gut and lung microbiome has a role in asthma

K Hufnagl, I Pali-Schöll, F Roth-Walter… - Seminars in …, 2020 - Springer
Worldwide 300 million children and adults are affected by asthma. The development of
asthma is influenced by environmental and other exogenous factors synergizing with …

Functional effects of the microbiota in chronic respiratory disease

KF Budden, SD Shukla, SF Rehman… - The lancet Respiratory …, 2019 - thelancet.com
The composition of the lung microbiome is increasingly well characterised, with changes in
microbial diversity or abundance observed in association with several chronic respiratory …

Cellular and molecular mechanisms of allergic asthma

ZI Komlósi, W van de Veen, N Kovács, G Szűcs… - Molecular aspects of …, 2022 - Elsevier
Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …

A biodiversity hypothesis

T Haahtela - Allergy, 2019 - Wiley Online Library
Biodiversity hypothesis states that contact with natural environments enriches the human
microbiome, promotes immune balance and protects from allergy and inflammatory …

Neutrophilic inflammation in asthma and association with disease severity

A Ray, JK Kolls - Trends in immunology, 2017 - cell.com
Asthma is a chronic inflammatory disorder of the airways. While the local infiltration of
eosinophils and mast cells, and their role in the disease have long been recognized …

Smoking and microbiome in oral, airway, gut and some systemic diseases

C Huang, G Shi - Journal of translational medicine, 2019 - Springer
The human microbiome harbors a diverse array of microbes which establishes a mutually
beneficial relation with the host in healthy conditions, however, the dynamic homeostasis is …

The microbiome and the respiratory tract

RP Dickson, JR Erb-Downward… - Annual review of …, 2016 - annualreviews.org
Although the notion that “the normal lung is free from bacteria” remains common in
textbooks, it is virtually always stated without citation or argument. The lungs are constantly …

[HTML][HTML] The respiratory tract microbiome and lung inflammation: a two-way street

GB Huffnagle, RP Dickson, NW Lukacs - Mucosal immunology, 2017 - Elsevier
The lungs are not sterile or free from bacteria; rather, they harbor a distinct microbiome
whose composition is driven by different ecological rules than for the gastrointestinal tract …

Targeting cell signaling in allergic asthma

SS Athari - Signal transduction and targeted therapy, 2019 - nature.com
Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …