Background Chronic rhinosinusitis (CRS) is a prevalent multifactorial disease process in
which bacteria are believed to play a role in the propagation of inflammation. Multiple …

Systems biology is an approach to understanding living systems that focuses on modeling
diverse types of high-dimensional interactions to develop a more comprehensive …

Asthma is a major global health issue. Over 300 million people worldwide suffer from this
chronic inflammatory airway disease. Typical clinical symptoms of asthma are characterized …

Asthma is a chronic airway inflammatory disease that is influenced by the interplay between
genetic factors and exposure to environmental allergens, microbes, or microbial products …

All body surfaces are exposed to a wide variety of microbes, which significantly influence
immune reactivity within the host. This review provides an update on some of the critical …

Background Nasal microbiota may influence asthma pathobiology. Objective We sought to
characterize the nasal microbiome of subjects with exacerbated asthma, nonexacerbated …

Asthma is a heterogeneous disease characterized by inflammation in the respiratory airways
which manifests clinically with wheezing, cough, and episodic periods of chest tightness; if …

It is well recognized that atopic sensitization is an important risk factor for asthma, both in
adults and in children. However, the role of allergy in severe asthma is still under debate …

Background The lung has a diverse microbiome that is modest in biomass. This microbiome
differs in asthmatic patients compared with control subjects, but the effects of clinical …

Severe asthma is “asthma which requires treatment with high dose inhaled corticosteroids
(ICS) plus a second controller (and/or systemic corticosteroids) to prevent it from becoming …