SILAC is based on direct addition of selected stable isotope amino acids into the cell culture
medium, allowing superior quantitative analysis of the cellular proteome compared to other …

Despite remarkable progress in proteomic methods, including improved detection limits and
sensitivity, these methods have not yet been established in routine clinical practice. The …

Most molecular hallmarks of cellular senescence have been identified in studies of cells
aged in vitro by driving them into replicative or stress-induced senescence. Comparatively …

Controlled vocabularies (CVs), ie a collection of predefined terms describing a modeling
domain, used for the semantic annotation of data, and ontologies are used in structured data …

Purpose.: To examine the presence and distribution of proteoglycan (PG) core proteins in
the adult human retina, choroid, and sclera. Methods.: Postmortem human eye tissue was …

Intact protein analysis via top-down mass spectrometry (MS) provides the unique capability
of fully characterizing protein isoforms and combinatorial post-translational modifications …

The most common technologies for quantitative determination of protein biomarkers are
immunoassays, which exist in various formats. Immunoassays offer sensitive and fast protein …

The application of quantitative proteomics provides a new and promising tool for
standardized toxicological research. However, choosing a suitable quantitative method still …

This Campbell systematic review examines the effectiveness of school‐based education
programmes for the prevention of child sexual abuse. The review summarises findings from …

Resistance to trastuzumab, which specifically target HER2-positive breast and gastric
cancer, can develop ultimately in cancer patients. However, the underlying mechanisms of …