THE PAST decade has witnessed an upsurge in our understanding of the hypothalamic
regulation of appetite. Expression of appetite or the motivational drive toward an energy …

The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin and
their pathophysiological roles are increasingly the subject of investigation. Evidence …

Ingestion of different nutrients, such as fats and sugars, normally produces different effects
on physiology, the brain, and behavior. However, they do share certain neural pathways for …

Recent studies in adult and weanling rats show that dietary fat, in close association with
circulating lipids, can stimulate expression of hypothalamic peptides involved in controlling …

Many homeostatic processes, including appetite and food intake, are controlled by
neuroendocrine circuits involving the CNS. The CNS also directly regulates adipocyte …

Melanin-concentrating hormone (MCH) has recently been proposed as both a central
stimulator and an inhibitor of food intake. To clarify its role, we investigated the effects of …

Progressive wasting is common in many types of cancer and is one of the most important
factors leading to early death in cancer patients. Weight loss is a potent stimulus to food …

Energy balance is maintained via a homeostatic system involving both the brain and the
periphery. A key component of this system is the hypothalamus. Over the past two decades …

Neuropeptides are essential for the regulation of appetite and body weight within the
hypothalamus. The understanding of the neuropeptide regulation of energy homeostasis …

Administration of ghrelin, an endogenous ligand for the GH secretagogue receptor 1a
(GHSR 1a), induces potent stimulating effects on GH secretion and food intake. However …