Abnormal vasculature is one of the most conspicuous traits of tumor tissue, largely
contributing to tumor immune evasion. The deregulation mainly arises from the potentiated …

Blood travels throughout the body in an extensive network of vessels–arteries, veins and
capillaries. This vascular network is not static, but instead dynamically remodels in response …

The VEGF–VEGFR2 (VEGF= vascular endothelial growth factor) signaling has been a
promising target in cancer therapy. However, because conventional anti-angiogenic …

Angiogenesis, the recruitment of new blood vessels, is a critical process for the growth,
expansion, and metastatic dissemination of developing tumors. Three types of cells make up …

Quantitative systems pharmacology (QSP) modeling is an emerging mechanistic
computational approach that couples drug pharmacokinetics/pharmacodynamics and the …

Generating realistic virtual patients from a limited amount of patient data is one of the major
challenges for quantitative systems pharmacology modeling in immuno-oncology …

Vascular endothelial growth factor (VEGF) is a notable chemokine that plays critical roles in
angiogenesis and vasculogenesis. The contemporary body of literature contains a …

In spite of treatment, severe angioproliferative pulmonary arterial hypertension (PAH)
remains a disease characterized by great morbidity and shortened survival. New treatment …

Fetal growth restriction (FGR), which most commonly results from suboptimal placental
function, substantially increases risks for adverse perinatal and long-term outcomes. The …

Alterations in the abundance or activities of alternative splicing regulators generate
alternatively spliced variants that contribute to multiple aspects of tumor establishment …