The incidence of stroke and dementia are diverging across the world, rising for those in low-
and middle-income countries and falling in those in high-income countries. This suggests …

The amyloid β peptide (Aβ) is a critical initiator that triggers the progression of Alzheimer's
Disease (AD) via accumulation and aggregation, of which the process may be caused by Aβ …

Alzheimer's disease is the most common cause of senile dementia in the United States and
Europe. At present, there is no effective treatment. Given the disease's prevalence and poor …

For 20 years the amyloid cascade hypothesis of Alzheimer disease (AD) has placed the
amyloid-β peptide (Aβ), formed from the amyloid precursor protein (APP), centre stage in the …

The only drugs currently approved for the treatment of Alzheimer's Disease (AD) are four
acetylcholinesterase inhibitors and the NMDA antagonist memantine. Apart from these …

Alzheimer's disease (AD) is the most common form of dementia. At the diagnostic stage, the
AD brain is characterized by the accumulation of extracellular amyloid plaques, intracellular …

Transgenic animals are extensively used to study in vivo gene function as well as to model
human diseases. The technology for producing transgenic animals exists for a variety of …

Purpose To investigate which type, frequency, duration, intensity, and volume of chronic
exercise might more strongly reduce pro-inflammatory cytokines and enhance anti …

Animal models for learning and memory have significantly contributed to novel strategies for
drug development and hence are an imperative part in the assessment of therapeutics …

J. Neurochem.(2012) 120, 660–666. Abstract Deposition of the amyloid‐β (Aβ) peptide in
senile plaques and cerebral Aβ angiopathy (CAA) can be stimulated in Aβ‐precursor protein …