Blood–brain barrier link to human cognitive impairment and Alzheimer's disease
Vascular dysfunction is frequently observed in disorders associated with cognitive
impairment, dementia and Alzheimer's disease (AD). Recent advances in neuroimaging and …
impairment, dementia and Alzheimer's disease (AD). Recent advances in neuroimaging and …
Retinal vasculopathy in Alzheimer's disease
The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …
SGLT2 inhibition via empagliflozin improves endothelial function and reduces mitochondrial oxidative stress: insights from frail hypertensive and diabetic patients
P Mone, F Varzideh, SS Jankauskas, A Pansini… - …, 2022 - Am Heart Assoc
Background: Frailty is a multidimensional condition often diagnosed in older adults with
hypertension and diabetes, and both these conditions are associated with endothelial …
hypertension and diabetes, and both these conditions are associated with endothelial …
Magnetic resonance imaging of blood–brain barrier permeability in dementia
Alzheimer's disease (AD) and cerebral small vessel disease (cSVD) are the two main
causes of dementia with blood–brain barrier (BBB) breakdown being a common contributor …
causes of dementia with blood–brain barrier (BBB) breakdown being a common contributor …
Stress and the gut-brain axis: Cognitive performance, mood state, and biomarkers of blood-brain barrier and intestinal permeability following severe physical and …
AN Varanoske, HL McClung, JJ Sepowitz… - Brain, behavior, and …, 2022 - Elsevier
Background Physical and psychological stress alter gut-brain axis activity, potentially
causing intestinal barrier dysfunction that may, in turn, induce cognitive and mood …
causing intestinal barrier dysfunction that may, in turn, induce cognitive and mood …
Imaging subtle leaks in the blood–brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions
Recent studies using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)
with gadolinium-based contrast agents (GBCA) have demonstrated subtle blood–brain …
with gadolinium-based contrast agents (GBCA) have demonstrated subtle blood–brain …
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease
M Bettinetti‐Luque, L Trujillo‐Estrada… - British Journal of …, 2024 - Wiley Online Library
Adipose tissue has recently been recognized as an important endocrine organ that plays a
crucial role in energy metabolism and in the immune response in many metabolic tissues …
crucial role in energy metabolism and in the immune response in many metabolic tissues …
Contributions of blood–brain barrier imaging to neurovascular unit pathophysiology of Alzheimer's disease and related dementias
The blood–brain barrier (BBB) plays important roles in the maintenance of brain
homeostasis. Its main role includes three kinds of functions:(1) to protect the central nervous …
homeostasis. Its main role includes three kinds of functions:(1) to protect the central nervous …
Regional differences in the link between water exchange rate across the blood–brain barrier and cognitive performance in normal aging
The blood–brain barrier (BBB) undergoes functional changes with aging which may
contribute to cognitive decline. A novel, diffusion prepared arterial spin labeling-based MRI …
contribute to cognitive decline. A novel, diffusion prepared arterial spin labeling-based MRI …
Retinal peri-arteriolar versus peri-venular amyloidosis, hippocampal atrophy, and cognitive impairment: exploratory trial
OM Dumitrascu, J Doustar, DT Fuchs… - Acta Neuropathologica …, 2024 - Springer
The relationship between amyloidosis and vasculature in cognitive impairment and
Alzheimer's disease (AD) pathogenesis is increasingly acknowledged. We conducted a …
Alzheimer's disease (AD) pathogenesis is increasingly acknowledged. We conducted a …