S-(+) enantiomer of ibuprofen (IBU) dexibuprofen (DXI) is known to be more potent than its R-
(−) form and exhibits many advantages over the racemic mixture of IBU such as lower …

Breast cancer is one of the most common cancers worldwide, which makes it a very
impactful malignancy in the society. Breast cancers can be classified through different …

Colchicine is a well-known compound with strong antiproliferative activity that has had
limited use in chemotherapy because of its toxicity. In order to create more potent anticancer …

Endometrial cancer (EC) is the 6th most common cancer in women around the world. Alone
in the United States (US), 66,200 new cases and 13,030 deaths are expected to occur in …

A novel series of 19 quinoline/1, 2, 4-triazole hybrid 6a-i and 7a-j was synthesized and
evaluated in vitro as dual COX-2/5-LOX inhibitors. Compounds 6e, 6i, and 7e displayed the …

Amines and amides, as N-containing compounds, are ubiquitous in pharmaceutically-active
scaffolds, natural products, agrochemicals, and peptides. Amides in nature bear a key …

Objective: Malaria is an ancient disease that still causes more than 200 million of cases 7
with high mortality globally. Identification of new drug targets and development of novel …

We describe a methodology for the amidation of carboxylic acids by generating
phosphonium salts in situ from N-chlorophthalimide and triphenylphosphine. Aliphatic …

Abstract Ubiquitin-specific protease (USP), an enzyme catalyzing protein deubiquitination, is
involved in biological processes related to metabolic disorders and cancer proliferation. We …

Herein, we described the synthesis of indole-tetrazole coupled aromatic amides (6a-o) and
evaluated their in vitro anticancer activity. Some of the compounds namely N-(4 …