Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …

An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …

Neurodegenerative disorders affect fifteen percent of the world's population and pose a
significant financial burden to all nations. Cognitive impairment is the seventh leading cause …

Methods and results: Novel work with biological clock genes that oversee circadian rhythm
may meet this critical need by focusing upon the pathways of the mechanistic target of …

Endothelial colony forming cells (ECFCs) represent the most suitable cellular substrate to
induce revascularization of ischemic tissues. Recently, optical excitation of the light-sensitive …

Background Patients with diabetes have accelerated vascular aging when compared with
healthy individuals. Hyperglycemia, especially intermittent high glucose (IHG), is the main …

Cardiovascular disease (CVD) comprises a range of major clinical cardiac and circulatory
diseases, which produce immense health and economic burdens worldwide. Currently …

Background Little is known about endogenous inhibitors of angiogenic growth factors. In this
study, we identified a novel endogenous anti-angiogenic factor expressed in pericytes and …

Capsaicin, a lipophilic, volatile compound, is responsible for the pungent properties of chili
peppers. In recent years, a significant increase in investigations into its properties has …

Loss of endothelial function is a common feature to all cardiovascular diseases (CVDs). One
of the risk factors associated with the development of CVDs is the hyperglycaemia that …