Abstract IL-4 and IL-13 are pleiotropic Th2 cytokines produced by a wide variety of different
cell types and responsible for a broad range of biology and functions. Physiologically, Th2 …

Abstract Chitinase‐3‐like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its
ability to regulate multiple biological processes, such as the inflammatory response and …

Alexander disease (AxD) is a leukodystrophy that primarily affects astrocytes and is caused
by mutations in the astrocytic filament gene GFAP. While astrocytes are thought to have …

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2, CD213A), a high-affinity membrane
receptor of the anti-inflammatory Th2 cytokine IL-13, is overexpressed in a variety of solid …

Epithelial injury, alternative macrophage accumulation, and fibroproliferation coexist in the
lungs of patients with idiopathic pulmonary fibrosis (IPF). Chitinase 3–like 1 (CHI3L1) is a …

Tumour-associated macrophages have been implicated in pancreatic ductal
adenocarcinoma (PDAC) therapy response and Extracellular vesicles (EVs) shed by …

Abstract Interleukin 13 receptor alpha 2 (IL13Rα2) is increasingly recognized as a relevant
player in cancer invasion and metastasis. Despite being initially considered a decoy …

Abstract Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates
inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of …

Chitinase-like proteins (CLPs) are lectins combining properties of cytokines and growth
factors. Human CLPs include YKL-40, YKL-39 and SI-CLP that are secreted by cancer cells …

Astrocytes are highly heterogeneous in their phenotype and function, which contributes to
CNS disease, repair, and aging; however, the molecular mechanism of their functional …