PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease

HZ Long, Y Cheng, ZW Zhou, HY Luo… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative
diseases that increased with aging. With the emergence of aging population, the health …

[HTML][HTML] Protective effects of curcumin against traumatic brain injury

D Khayatan, SM Razavi, ZN Arab, AH Niknejad… - Biomedicine & …, 2022 - Elsevier
Neuroinflammation is a key pathophysiological mechanism implicated in the
neurodegenerative condition. One such condition implicating neuroinflammation is traumatic …

[HTML][HTML] Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke

Z Shen, M Xiang, C Chen, F Ding, Y Wang… - Biomedicine & …, 2022 - Elsevier
Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

Chitosan-based nanocarriers for encapsulation and delivery of curcumin: A review

Q Hu, Y Luo - International journal of biological macromolecules, 2021 - Elsevier
To overcome the poor aqueous solubility and bioavailability of curcumin, emphasize its
functional features, and broaden its applications in the food and pharmaceutical industries …

Mechanistic insights into the link between gut dysbiosis and major depression: an extensive review

S Sonali, B Ray, H Ahmed Tousif, AG Rathipriya… - Cells, 2022 - mdpi.com
Depression is a highly common mental disorder, which is often multifactorial with sex,
genetic, environmental, and/or psychological causes. Recent advancements in biomedical …

[HTML][HTML] Curcuma longa (Turmeric): Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicity profiles—A review

EJ Iweala, ME Uche, ED Dike, LR Etumnu… - Pharmacological …, 2023 - Elsevier
Introduction Curcuma longa, popularly known as Turmeric, is a rhizomatous herbaceous
perennial plant used in folk medicine for the treatment, prevention, and management of …

Curcumin's nanomedicine formulations for therapeutic application in neurological diseases

B Salehi, D Calina, AO Docea, N Koirala… - Journal of Clinical …, 2020 - mdpi.com
The brain is the body's control center, so when a disease affects it, the outcomes are
devastating. Alzheimer's and Parkinson's disease, and multiple sclerosis are brain diseases …

Anti-Parkinsonian therapy: strategies for crossing the blood–brain barrier and nano-biological effects of nanomaterials

G Cheng, Y Liu, R Ma, G Cheng, Y Guan, X Chen… - Nano-micro letters, 2022 - Springer
Abstract Parkinson's disease (PD), a neurodegenerative disease that shows a high
incidence in older individuals, is becoming increasingly prevalent. Unfortunately, there is no …

Turmeric and its bioactive constituents trigger cell signaling mechanisms that protect against diabetes and cardiovascular diseases

HA Zhang, DD Kitts - Molecular and cellular biochemistry, 2021 - Springer
Turmeric, the rhizome of Curcuma longa plant belonging to the ginger family Zingiberaceae,
has a history in Ayurvedic and traditional Chinese medicine for treatment of chronic …

Brain-targeted biomimetic nanodecoys with neuroprotective effects for precise therapy of Parkinson's disease

Y Liu, J Luo, Y Liu, W Liu, G Yu, Y Huang… - ACS Central …, 2022 - ACS Publications
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual loss
of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein …