[HTML][HTML] T cells in health and disease
L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
[HTML][HTML] Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms
Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …
[HTML][HTML] A COVID-19 peptide vaccine for the induction of SARS-CoV-2 T cell immunity
T cell immunity is central for the control of viral infections. CoVac-1 is a peptide-based
vaccine candidate, composed of SARS-CoV-2 T cell epitopes derived from various viral …
vaccine candidate, composed of SARS-CoV-2 T cell epitopes derived from various viral …
Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice
J Ramos da Silva, K Bitencourt Rodrigues… - Science Translational …, 2023 - science.org
As mRNA vaccines have proved to be very successful in battling the coronavirus disease
2019 (COVID-19) pandemic, this new modality has attracted widespread interest for the …
2019 (COVID-19) pandemic, this new modality has attracted widespread interest for the …
CD4+ T cell help in cancer immunology and immunotherapy
Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within
a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish …
a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish …
[HTML][HTML] Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy
A Basu, G Ramamoorthi, G Albert, C Gallen… - Frontiers in …, 2021 - frontiersin.org
Current success of immunotherapy in cancer has drawn attention to the subsets of TH cells
in the tumor which are critical for activation of anti-tumor response either directly by …
in the tumor which are critical for activation of anti-tumor response either directly by …
[HTML][HTML] Dendritic cells and their role in immunotherapy
Despite significant advances in the field of cancer immunotherapy, the majority of patients
still do not benefit from treatment and must rely on traditional therapies. Dendritic cells have …
still do not benefit from treatment and must rely on traditional therapies. Dendritic cells have …
[HTML][HTML] Dendritic cells in cancer immunology
TL Murphy, KM Murphy - Cellular & molecular immunology, 2022 - nature.com
The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in
tumor immunology research because ICT was discovered through basic studies of immune …
tumor immunology research because ICT was discovered through basic studies of immune …
[HTML][HTML] Inflammation–nature's way to efficiently respond to all types of challenges: implications for understanding and managing “the epidemic” of chronic diseases
Siloed or singular system approach to disease management is common practice,
developing out of traditional medical school education. Textbooks of medicine describe a …
developing out of traditional medical school education. Textbooks of medicine describe a …
[HTML][HTML] Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation
S Guedan, AD Posey Jr, C Shaw, A Wing, T Da… - JCI insight, 2018 - ncbi.nlm.nih.gov
Successful tumor eradication by chimeric antigen receptor–expressing (CAR-expressing) T
lymphocytes depends on CAR T cell persistence and effector function. We hypothesized that …
lymphocytes depends on CAR T cell persistence and effector function. We hypothesized that …