Ubiquitin–proteasome system (UPS) is a selective proteolytic system that is associated with
the expression or function of target proteins and participates in various physiological and …

This year marks the fourth decade of research into the protein SET, which was discovered in
1992. SET was initially identified as an oncoprotein, but later, it was shown to be a …

Splicing-based transcriptome-wide association studies (splicing-TWASs) of breast cancer
have the potential to identify susceptibility genes. However, existing splicing-TWASs test the …

Breast cancer has become the most prevalent malignancy worldwide; however, therapeutic
efficacy is far from satisfactory. To alleviate the burden of this disease, it is imperative to …

Triple-negative breast cancer (TNBC) is an exceptionally aggressive subtype of breast
cancer. Despite the recognized interplay between tumors and tumor-associated …

Endocrine therapy (ET), also known as hormone therapy, refers to the treatment of tumors by
regulating and changing the endocrine environment and hormone levels. Its related …

Cockayne syndrome (CS) is a rare hereditary autosomal recessive disorder primarily
caused by mutations in Cockayne syndrome protein A (CSA) or B (CSB). While many of the …

The SET gene has four transcripts reported in NCBI, coding two isoforms of SET proteins.
The most known function of SET protein is inhibiting protein phosphatase 2A, a tumor …

Breast cancer (BC) is a highly frequent malignant tumor that poses a serious threat to
women's health and has different molecular subtypes, histological subtypes, and biological …

Oncoprotein SE translocation (SET) is frequently overexpressed in different types of tumors
and correlated with poor prognosis of cancer patients. Targeting SET has been considered a …