This study aimed to explore the influence of hesperidin on the polarization of microglia to
clarify the key mechanism of regulating the polarization of M2 microglia. C57BL/6 mice were …

HIV persistence in the CNS despite antiretroviral therapy may cause neurological disorders
and poses a critical challenge for HIV cure. Understanding the pathobiology of HIV-infected …

Accumulating evidence has demonstrated that the pathogenesis of epilepsy is linked to
neuroinflammation and cerebrovascular dysfunction. Peripheral immune cell invasion into …

The percentage of macrophage subpopulations based on their origins in the adult cochlea
remains unclear. This study aimed to elucidate the origins of cochlear macrophages during …

Increasing evidence hints to the central role of neuroinflammation in the development of post‑
stroke depression. Danger signals released in the acute phase of ischemia trigger microglial …

New research shows that disease-associated microglia in neurodegenerative brains present
features of elevated phagocytosis, lysosomal functions, and lipid metabolism, which benefit …

We recently reported that neonatal ischemia induces microglia/macrophage activation three
days post-ischemia. We also found that female mice sustained smaller infarcts than males …

Highlights•Drug repurposing may be a novel approach towards developing adjunct therapy
for stroke.•Drug repurposing avoids time and expenses associated with new drug-discovery …

Background Harmful effects of activated microglia are due, in part, to the formation of
peroxynitrite radicals, which is attributable to the upregulation of inducible nitric oxide (NO) …

Microglial activation and microglia‐mediated inflammation play an important role in the
occurrence, development, and outcome of stroke. Brain injury induces the activation and …