SUMMARY A substantial body of epidemiological and experimental evidence suggests that
serum uric acid is an important, independent risk factor for cardiovascular and renal disease …

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

Uric acid has been implicated in the pathophysiology of renal disease; however renal
clearance makes a causal relationship difficult to prove. We examine the current literature to …

Hypertension and hypertension-associated ESRD are epidemic in society. The mechanisms
responsible for renal progression in mild to moderate hypertension and those groups most …

Post-hoc analyses of the GREACE and the LIFE trials have renewed the interest in elevated
serum uric acid (SUA) as a factor contributing to atherosclerotic cardiovascular disease …

Hyperuricemia has long been recognized to be associated with increased cardiovascular
risk, including risk of developing hypertension. Epidemiological findings suggest that the link …

Two risk factors for the development and progression of cancers that are amenable to life
style modification are chronic inflammation and the metabolic syndrome. This review …

More than a century of research on the renin-angiotensin system (RAS) has uncovered the
widespread involvement of angiotensin II (Ang II) in the pathophysiology of cardiovascular …

Elevated serum uric acid (SUA) levels are commonly seen in patients with the metabolic
syndrome (MetS). Several mechanisms, both direct and indirect, connect the increased SUA …

Importance The prevalence of gout has increased in recent decades. Several clinical studies
have demonstrated an association between gout and coronary heart disease, but direct …