Developing nociceptor-selective treatments for acute and chronic pain

S Jayakar, J Shim, S Jo, BP Bean, I Singeç… - Science translational …, 2021 - science.org
Despite substantial efforts dedicated to the development of new, nonaddictive analgesics,
success in treating pain has been limited. Clinically available analgesic agents generally …

The role of hydrogen sulfide in regulation of cell death following neurotrauma and related neurodegenerative and psychiatric diseases

S Rodkin, C Nwosu, A Sannikov, M Raevskaya… - International Journal of …, 2023 - mdpi.com
Injuries of the central (CNS) and peripheral nervous system (PNS) are a serious problem of
the modern healthcare system. The situation is complicated by the lack of clinically effective …

Macrophage migration inhibitory factor (MIF) makes complex contributions to pain-related hyperactivity of nociceptors after spinal cord injury

A Bavencoffe, EA Spence, MY Zhu… - Journal of …, 2022 - Soc Neuroscience
Neuropathic pain is a major, inadequately treated challenge for people with spinal cord
injury (SCI). While SCI pain mechanisms are often assumed to be in the CNS, rodent studies …

Molecular approaches for spinal cord injury treatment

FM de Almeida, SA Marques… - Neural Regeneration …, 2023 - journals.lww.com
Injuries to the spinal cord result in permanent disabilities that limit daily life activities. The
main reasons for these poor outcomes are the limited regenerative capacity of central …

[HTML][HTML] The role of exercise in the alleviation of neuropathic pain following traumatic spinal cord injuries: a systematic review and meta-analysis

A Toloui, HA Ramawad, P Gharin, AR Vaccaro… - Neurospine, 2023 - ncbi.nlm.nih.gov
Objective The objective of this systematic review and meta-analysis was to assess the
efficacy of exercise in neuropathic pain following traumatic spinal cord injuries. Methods The …

Leveraging the ATP‐P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications

Y Yin, L Wei, EA Caseley… - Medicinal Research …, 2023 - Wiley Online Library
The P2X7 receptor is an exceptional member of the P2X purinergic receptor family, with its
activation requiring high concentrations of extracellular adenosine 5ʹ‐triphosphate (ATP) …

Active or passive pain coping: Which predicts daily physical and psychosocial functioning in people with chronic pain and spinal cord injury?

D Kuzu, S Kim, AL Kratz - Rehabilitation psychology, 2022 - psycnet.apa.org
Purpose/Objective: Despite medical and psychotherapeutic treatments, chronic pain is one
of the most challenging and disabling conditions for individuals with spinal cord injury (SCI) …

Evaluation of a Physical-Psychological Integrative (PPI) intervention for community-dwelling spinal cord injury survivors: Study protocol of a preliminary randomized …

Y Li, A Wong, WM Chung, M Li, A Molasiotis… - Plos one, 2023 - journals.plos.org
Introduction There is a considerably large group of community-dwelling spinal cord injury
(SCI) survivors living with low quality of life. Physical inactivity, depression, and chronic pain …

Feasibility of brief, hypnotic enhanced cognitive therapy for SCI-related pain during inpatient rehabilitation

AJ Starosta, CH Bombardier, F Kahlia, J Barber… - Archives of Physical …, 2024 - Elsevier
Abstract Objectives (1) Adapt evidence-based hypnosis-enhanced cognitive therapy (HYP-
CT) for inpatient rehabilitation setting; and (2) determine feasibility of a clinical trial …

The relationship between physical activity level and functional status of subjects with high spinal cord injury

E Szeliga, A Brzozowska-Magoń, R Borys… - International Journal of …, 2022 - mdpi.com
Background. Spinal cord injuries are one of disability in Poland and in the world. Methods:
80 subjects with a transverse injury of the cervical spinal cord were enrolled in the study …