Recent advances in the monitoring, modelling and control of crystallization systems
Crystallization is one of the most important unit operations used for the separation and
purification of crystalline solid products. Appropriate design and control of the crystallization …
purification of crystalline solid products. Appropriate design and control of the crystallization …
Advances and new directions in crystallization control
The academic literature on and industrial practice of control of solution crystallization
processes have seen major advances in the past 15 years that have been enabled by …
processes have seen major advances in the past 15 years that have been enabled by …
Assessment of recent process analytical technology (PAT) trends: a multiauthor review
This multiauthor review article aims to bring readers up to date with some of the current
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …
Continuous plug flow crystallization of pharmaceutical compounds
AJ Alvarez, AS Myerson - Crystal Growth & Design, 2010 - ACS Publications
Crystallization processes in the pharmaceutical industry are usually designed to obtain
crystals with controlled size, shape, purity, and polymorphic form. Knowledge of the process …
crystals with controlled size, shape, purity, and polymorphic form. Knowledge of the process …
Progress and opportunities for utilizing seeding techniques in crystallization processes
Seeding is a significant but challenging task for optimizing crystallization process operation,
product quality, and process efficiency. With the development of modern crystallization …
product quality, and process efficiency. With the development of modern crystallization …
[PDF][PDF] From form to function: Crystallization of active pharmaceutical ingredients
N Variankaval, AS Cote, MF Doherty - AIChE journal, 2008 - cepac.cheme.cmu.edu
Since the introduction of aspirin in 1899, and more par-ticularly since the advent of antibiotic
''wonder drugs''in the 1940s, society has come to rely on the widespread availability of …
''wonder drugs''in the 1940s, society has come to rely on the widespread availability of …
Overview of secondary nucleation: From fundamentals to application
S Xu, Z Hou, X Chuai, Y Wang - Industrial & Engineering …, 2020 - ACS Publications
Secondary nucleation can bring the crystallization process into a more easily controlled
state, and it is playing an important role in controlling crystal size distribution, polymorphism …
state, and it is playing an important role in controlling crystal size distribution, polymorphism …
The impact of direct nucleation control on crystal size distribution in pharmaceutical crystallization processes
The control of crystal size distribution (CSD) in pharmaceutical crystallization is of primary
importance, as downstream processes such as filtration or drying are greatly affected by the …
importance, as downstream processes such as filtration or drying are greatly affected by the …
[HTML][HTML] Pharmaceutical crystallisation processes from batch to continuous operation using MSMPR stages: Modelling, design, and control
In pharmaceuticals manufacturing, the conversion of conventional batch crystallisations to
continuous mode has the potential for intensified, compact operation and more consistent …
continuous mode has the potential for intensified, compact operation and more consistent …
Modelling and control of combined cooling and antisolvent crystallization processes
Although for decades nearly all pharmaceuticals have been purified by crystallization, there
have been a disproportionate number of problems associated with the operation and control …
have been a disproportionate number of problems associated with the operation and control …