Probiotic‐inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the Gut Microbiome

J Xu, J Xu, T Shi, Y Zhang, F Chen, C Yang… - Advanced …, 2023 - Wiley Online Library
Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …

A valence‐engineered self‐cascading antioxidant nanozyme for the therapy of inflammatory bowel disease

Q Wang, C Cheng, S Zhao, Q Liu, Y Zhang… - Angewandte …, 2022 - Wiley Online Library
Antioxidant treatment strategy by scavenging reactive oxygen species (ROS) is a highly
effective disease treatment option. Nanozymes with multiple antioxidant activities can cope …

Oral hydrogel microbeads-mediated in situ synthesis of selenoproteins for regulating intestinal immunity and microbiota

J Ouyang, B Deng, B Zou, Y Li, Q Bu… - Journal of the …, 2023 - ACS Publications
Selenoprotein plays a crucial role in immune cells and inflammatory regulation. However, as
a protein drug that is easily denatured or degraded in the acidic environment of the stomach …

Colon‐targeted adhesive hydrogel microsphere for regulation of gut immunity and flora

H Liu, Z Cai, F Wang, L Hong, L Deng… - Advanced …, 2021 - Wiley Online Library
Intestinal immune homeostasis and microbiome structure play a critical role in the
pathogenesis and progress of inflammatory bowel disease (IBD), whereas IBD treatment …

A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease

C Shi, J Dawulieti, F Shi, C Yang, Q Qin, T Shi… - Science …, 2022 - science.org
A therapeutic strategy that targets multiple proinflammatory factors in inflammatory bowel
disease (IBD) with minimal systemic side effects would be attractive. Here, we develop a …

Reactive oxygen species‐regulating strategies based on nanomaterials for disease treatment

C Zhang, X Wang, J Du, Z Gu, Y Zhao - Advanced Science, 2021 - Wiley Online Library
Reactive oxygen species (ROS) play an essential role in physiological and pathological
processes. Studies on the regulation of ROS for disease treatments have caused wide …

Chemically and biologically engineered bacteria‐based delivery systems for emerging diagnosis and advanced therapy

Z Li, Y Wang, J Liu, P Rawding, J Bu… - Advanced …, 2021 - Wiley Online Library
Bacteria are one of the main groups of organisms, which dynamically and closely participate
in human health and disease development. With the integration of chemical biotechnology …

Mussel-inspired chemistry: a promising strategy for natural polysaccharides in biomedical applications

F Liu, X Liu, F Chen, Q Fu - Progress in Polymer Science, 2021 - Elsevier
Polysaccharides are a kind of natural biopolymers and have been widely applied in various
fields, especially biomedical applications, due to their fascinating properties, such as …

Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: A review

Y Ouyang, J Zhao, S Wang - International journal of biological …, 2023 - Elsevier
Hydrogel is a three-dimensional network polymer material rich in water. It is widely used in
the biomedical field because of its unique physical and chemical properties and good …

An Orally Administered CeO2@Montmorillonite Nanozyme Targets Inflammation for Inflammatory Bowel Disease Therapy

S Zhao, Y Li, Q Liu, S Li, Y Cheng… - Advanced Functional …, 2020 - Wiley Online Library
Safe, effective, and convenient administration of therapeutic nanomaterials is one of the
greatest difficulties in nanomedicine. To tackle this challenge, a system which couples multi …