Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-
accumulation of ROS causes premature aging and/or death and is associated with various …

Ulcerative colitis is the most prevalent forms of inflammatory bowel diseases and a refractory
autoimmune disease and affects millions of people worldwide. Herein, we develop an oral …

As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel
disease (IBD) is characterized by recurrent intestinal mucosal inflammation. Oral …

The exciting success of NBTXR3 in the clinic has triggered a tumult of activities in the design
and development of hafnium-based nanoparticles. However, due to the concerns of …

Compared to injection administration, oral administration is free of discomfort, wound
infection, and complications and has a higher compliance rate for patients with diverse …

Inflammatory bowel disease (IBD) is a chronic gastrointestinal tract disorder characterized
by uncontrolled inflammatory responses to the disrupted intestinal epithelial barrier and gut …

As a result of its ability to target certain drugs and/or peptides to the colonic region for the
treatment of several diseases while avoiding systemic absorption and potential side effects …

Although nano-systems can promote the cellular internalization, polymeric nanoparticles
(NPs) are easily to be destroyed or eliminated in the gastrointestinal tract, which leads to …

Regulation of CRISPR-Cas9 functions in vivo is conducive to developing precise therapeutic
genome editing. Here, we report a CRISPR-Cas9 prodrug nanosystem (termed …

Microorganisms have been extensively applied as active biotherapeutic agents or drug
delivery vehicles for antitumor treatment because of their unparalleled bio-functionalities …