Hyaluronic acid (HA) is key to the stability of the internal environment of tissues. HA content
in tissues gradually decreases with age, causing age-related health problems. Exogenous …

The overexpression of reactive oxygen and nitrogen species (RONS) in the colonic mucosa
destroys the mucosa and its barrier, accelerating the occurrence of inflammatory bowel …

Imbalance in the tissue microenvironment is the main obstacle to drug delivery and
distribution in the human body. Before penetrating the pathological tissue microenvironment …

Macrophages, an important component of the innate immune response, are a key regulator
of intestinal microenvironment homeostasis. These cells essentially contribute to chronic …

The low viability during gastrointestinal transit and poor mucoadhesion considerably limits
the effectiveness of Ligilactobacillus salivarius Li01 (Li01) in regulating gut microbiota and …

The etiology of inflammatory bowel disease (IBD) is extremely complex and related to an
excessive immune response that results in the pathologically release of reactive oxygen …

Manipulation of gut microbiota by bacterial metabolites has shown protective effects against
colitis; while the efficacy is strictly limited by the poor oral delivery efficiency and single drug …

Ulcerative colitis (UC) is a chronic or relapsing inflammatory disease with limited therapeutic
outcomes. Pterostilbene (PSB) is a polyphenol-based anti-oxidant that has received …

With the rapid development and high therapeutic efficiency and biosafety of gas-involving
theranostics, hydrogen medicine has been particularly outstanding because hydrogen gas …

The active stages of intestinal inflammation and the pathogenesis of ulcerative colitis are
associated with superficial mucosal damage and intermittent wounding that leads to …