Proteins are one of the most important and resourceful biomolecules that find applications in
health, industry, medicine, research, and biotechnology. Given its tremendous relevance …

Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, are the
largest selling class of drugs prescribed for the pharmacological treatment of …

Enzyme engineering usually generates trade‐offs between activity, stability, and selectivity.
Herein, we report semirational engineering of an aldo–keto reductase (AKR) KmAKR for …

Abstract tert-Butyl (3R, 5S)-6-chloro-3, 5-dihydroxyhexanoate ((3R, 5S)-CDHH) is the key
intermediate for synthesis of atorvastatin and rosuvastatin. Carbonyl reductase exhibits …

Aldo‐keto reductases (AKRs) are important biocatalysts that can be used to synthesize
chiral pharmaceutical alcohols. In this study, the catalytic activity and stereoselectivity of a …

Loops typically allosterically communicate with active sites, and their conformational
dynamics can affect the catalytic properties of enzymes. Herein, by manipulating the loop …

The short‐and medium‐chain dehydrogenase/reductase superfamilies are responsible for
most chiral alcohol production in laboratories and industries. In nature, they participate in …

In this study, recombinant E. coli BL21 (DE3)/pCDFDuet-1-XR-GDH harboring xylose
reductase (XR) and glucose dehydrogenase (GDH) were immobilized and applied for the …

Iminodiacetic acid (IDA) is widely used as an intermediate in the manufacturing of chelating
agents, glyphosate herbicides and surfactants. To improve activity and tolerance to the …

The thermostable fungus, Thermoascus aurantiacus M-2, which produces a novel
acidophilic and thermostable xylanase was isolated and identified based on its morphology …