Ginkgetin: A natural biflavone with versatile pharmacological activities

M Adnan, A Rasul, G Hussain, MA Shah… - Food and Chemical …, 2020 - Elsevier
Natural products, being richly endowed with curative powers, have become spotlight for
biomedical and pharmaceutical research to develop novel therapeutics during recent years …

Platinum drugs and taxanes: can we overcome resistance?

EV Sazonova, GS Kopeina, EN Imyanitov… - Cell death …, 2021 - nature.com
Cancer therapy is aimed at the elimination of tumor cells and acts via the cessation of cell
proliferation and induction of cell death. Many research publications discussing the …

Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products

MM Rahman, MT Sarker, MA Alam Tumpa… - Frontiers in …, 2022 - frontiersin.org
Cancer is commonly thought to be the product of irregular cell division. According to the
World Health Organization (WHO), cancer is the major cause of death globally. Nature offers …

Dual relationship between long non-coding RNAs and STAT3 signaling in different cancers: New insight to proliferation and metastasis

M Ashrafizadeh, MH Gholami, S Mirzaei, A Zabolian… - Life sciences, 2021 - Elsevier
Uncontrolled growth and metastasis of cancer cells is an increasing challenge for
overcoming cancer, and improving survival of patients. Complicated signaling networks …

Inflammation suppression in doxorubicin-induced cardiotoxicity: natural compounds as therapeutic options

F Yarmohammadi, H Karbasforooshan… - Naunyn-Schmiedeberg's …, 2021 - Springer
Doxorubicin (DOX) is a potent chemotherapeutic agent; however, the accompanying
cardiotoxicity is a significant complication of the usefulness of treatment with DOX. Multiple …

The cross-talk between LncRNAs and JAK-STAT signaling pathway in cancer

A Hjazi, RF Obaid, SS Ali, B Abdullaev… - … -Research and Practice, 2023 - Elsevier
Long non-coding RNAs (lncRNAs) are non-coding RNAs that were transcribed from the
human genome and have become important regulators in a number of cellular activities …

The neuroprotective effects and therapeutic potential of the chalcone cardamonin for Alzheimer's disease

K Barber, P Mendonca, KFA Soliman - Brain Sciences, 2023 - mdpi.com
Neurodegenerative diseases (ND) include a wide range of conditions that result from
progressive damage to the neurons. Alzheimer's disease (AD) is one of the most common …

Molecular mechanisms of antiproliferative effects of natural chalcones

R Michalkova, L Mirossay, M Gazdova, M Kello… - Cancers, 2021 - mdpi.com
Simple Summary Despite the important progress in cancer treatment in the past decades,
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …

Investigation on the mechanisms by which the herbal remedies induce anti-prostate cancer activity: uncovering the most practical natural compound

A Poustforoosh, S Faramarz… - Journal of …, 2024 - Taylor & Francis
Prostate cancer (PCa) is one of the most reported cancers among men worldwide. Targeting
the essential proteins associated with PCa could be a promising method for cancer …

Antioxidant and anti-inflammatory mechanisms of Cardamonin through Nrf2 activation and NF-kB suppression in LPS-Activated BV-2 microglial cells

K Barber, P Mendonca, JA Evans… - International Journal of …, 2023 - mdpi.com
Chronic oxidative stress (OS) and inflammation are implicated in developing and
progressing neurodegenerative diseases (NDs). The chronic activation of microglia cells …