AMD3100, also known as plerixafor, was originally developed as an anti-human
immunodeficiency virus (HIV) drug, and later characterized as a CXC chemokine receptor …

Mobilization of peripheral blood stem cells (PBSC) in healthy volunteers with granulocyte
colony-stimulating factor (G-CSF) is currently carried out at many institutions worldwide. This …

Mouse and human fibroblasts were the first cell types successfully reprogrammed by ectopic
expression of OCT4, SOX2, KLF4, and c-MYC (OSKM)(Lowry et al., 2008; Maherali et al …

Human induced pluripotent stem (iPS) cells derived from somatic cells hold promise to
develop novel patient-specific cell therapies and research models for inherited and acquired …

Induced pluripotent stem cells (iPSC) provide an invaluable resource for regenerative
medicine as they allow the generation of patient-specific progenitors with potential value for …

Background Zarzio®, a new recombinant human granulocyte colony-stimulating factor
(filgrastim), was evaluated in healthy volunteers and neutropenic patients in phase I and III …

Precise molecular characterization of circulating polymorphonuclear myeloid-derived
suppressor cells (PMN-MDSCs) is hampered by their mixed composition of mature and …

Background Certain disadvantages of the standard hematopoietic stem and progenitor cell
(HSPC) mobilizing agent G-CSF fuel the quest for alternatives. We herein report results of a …

Successfully reprogramming somatic cells to a pluripotent state generates induced
pluripotent stem (iPS) cells (or iPSCs), which have extensive self-renewal capacity like …

Granulocyte colony‐stimulating factor (G‐CSF) was originally discovered in the context of
hematopoiesis. However, the identification of the G‐CSF receptor (G‐CSFR) being …