Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

Cell signaling in response to an array of diverse stress stimuli converges on the
phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2). Phosphorylation of …

Forkhead box O (FoxO) transcription factors are downstream targets of the serine/threonine
protein kinase B (PKB)/Akt. The Akt kinase regulates processes of cellular proliferation and …

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …

Alterations of signal transduction pathways leading to uncontrolled cellular proliferation,
survival, invasion, and metastases are hallmarks of the carcinogenic process. The …

Trastuzumab is a successful rationally designed ERBB2-targeted therapy. However, about
half of individuals with ERBB2-overexpressing breast cancer do not respond to trastuzumab …

The contribution of the nucleolus to cancer is well established with respect to its traditional
role in facilitating ribosome biogenesis and proliferative capacity. More contemporary …

Widespread mRNA 3′ UTR shortening through alternative polyadenylation promotes tumor
growth in vivo. A prevailing hypothesis is that it induces proto-oncogene expression in cis …

Identifying putative biomarkers of clinical outcomes in cancer is crucial for successful
enrichment, and for the selection of patients who are the most likely to benefit from a specific …