The world demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has a minimal impact on the environment will …

Climate change imposes a severe threat to agricultural systems, food security, and human
nutrition. Meanwhile, efforts in crop and livestock gene editing have been undertaken to …

Myostatin (MSTN) is a dominant inhibitor of skeletal muscle development and growth.
Mutations in MSTN gene can lead to muscle hypertrophy or double-muscled (DM) …

Studies to evaluate the therapeutic potential of stem cells in humans would benefit from
more realistic animal models. In veterinary medicine, companion animals naturally develop …

Genome editing followed by reproductive cloning was previously used to produce two
hornless dairy bulls. We crossed one genome-edited dairy bull, homozygous for the …

Accelerated development of novel CRISPR/Cas9-based genome editing techniques
provides a feasible approach to introduce a variety of precise modifications in the …

Genetically engineered (GE) livestock were first reported in 1985, and yet only a single GE
food animal, the fast-growing AquAdvantage salmon, has been commercialized. There are …

Genetically modified pigs for biomedical applications have been mainly generated using the
somatic cell nuclear transfer technique; however, this approach requires complex …

Regenerative medicine aims to restore the normal function of diseased or damaged cells,
tissues, and organs using a set of different approaches, including cell-based therapies. In …

Predictable, clean genetic modification (GM) in livestock is important for reliable
phenotyping and biosafety. Here we reported the generation of isozygous, functional …