Drug-induced phospholipidosis is characterized by intracellular accumulation of
phospholipids with lamellar bodies, most likely from an impaired phospholipid metabolism of …

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by
progressive loss of pulmonary function. Drug-induced interstitial lung disease has been …

Microarray technology, which allows one to quantitate the expression of thousands of genes
simultaneously, has begun to have a major impact on many different areas of drug discovery …

Phospholipidosis induced by drugs with a cationic amphiphilic structure is a generalized
condition in humans and animals that is characterized by an intracellular accumulation of …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder and is the most common
cause of progressive dementia in aging. Research on AD therapy has been partly …

Drug-induced phospholipidosis (PLDsis) is an excessive accumulation of polar
phospholipids in cells or tissues/organs caused by xenobiotics. Numerous drugs and …

Transcriptomic analysis is a powerful method in the utilization of New Approach Methods
(NAMs) for identifying mechanisms of toxicity and application to hazard characterization …

Amiodarone is widely used to treat cardiac arrhythmias and is very effective in preventing
these disorders. However, its use is limited by a wide range of adverse effects, mainly …

Amiodarone (AD) is a highly efficient antiarrhythmic drug with potentially serious side effects.
Severe pulmonary toxicity is reported in patients receiving AD even at low doses and may …

Several antioxidants have been shown to reduce lysosomal phospholipidosis, which is a
potential mechanism of amiodarone toxicity, and prevent amiodarone toxicity by antioxidant …