Cellular behavior is continuously affected by microenvironmental forces through the process
of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical …

The organization of microtubule networks is crucial for controlling chromosome segregation
during cell division, for positioning and transport of different organelles, and for cell polarity …

As germ cells progress through spermatogenesis, they undergo a dramatic transformation,
wherein a single, diploid spermatogonial stem cell ultimately produces thousands of highly …

Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin
regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear …

Since the identification of the first disease causing mutation in the gene coding for emerin, a
transmembrane protein of the inner nuclear membrane, hundreds of mutations and variants …

Apoptosis is characterized by the destruction of essential cell organelles, including the cell
nucleus. The nuclear envelope (NE) separates the nuclear interior from the cytosol. During …

Abstract Nesprins-1 and-2 are highly expressed in skeletal and cardiac muscle and together
with SUN (Sad1p/UNC84)-domain containing proteins and lamin A/C form the LInker of …

Distinctly organized microtubule networks contribute to the function of differentiated cell
types such as neurons, epithelial cells, skeletal myotubes, and cardiomyocytes. In striated …

The nuclear lamina is a proteinaceous network of filaments that provide both structural and
gene regulatory functions by tethering proteins and large domains of DNA, the so-called …

One of the major cellular mechanisms to ensure cellular protein homeostasis is the
endoplasmic reticulum (ER) stress response. This pathway is triggered by accumulation of …