[HTML][HTML] Recent advances in anti-tuberculosis drug discovery based on hydrazide–hydrazone and thiadiazole derivatives targeting inhA

Y Teneva, R Simeonova, V Valcheva, VT Angelova - Pharmaceuticals, 2023 - mdpi.com
Tuberculosis is an extremely serious problem of global public health. Its incidence is
worsened by the presence of multidrug-resistant (MDR) strains of Mycobacterium …

9 months of delamanid, linezolid, levofloxacin, and pyrazinamide versus conventional therapy for treatment of fluoroquinolone-sensitive multidrug-resistant …

J Mok, M Lee, DK Kim, JS Kim, BW Jhun, KW Jo… - The Lancet, 2022 - thelancet.com
Background With the introduction of new anti-tuberculosis drugs, all-oral regimens with
shorter treatment durations for multidrug-resistant tuberculosis have been anticipated. We …

Mycobacteriophages: therapeutic approach for mycobacterial infections

SK Raman, DVS Reddy, V Jain, U Bajpai, A Misra… - Drug Discovery …, 2024 - Elsevier
Tuberculosis (TB) is a significant global health threat, and cases of infection with non-
tuberculous mycobacteria (NTM) causing lung disease (NTM-LD) are rising. Bacteriophages …

[HTML][HTML] Comparing timelines and evidence available to support new TB, HIV, and HCV drug approvals: The same, only different

A LaHood, R Rahman, L McKenna, M Frick, CD Mitnick - Plos one, 2022 - journals.plos.org
Background Tuberculosis (TB), human immunodeficiency virus (HIV), and hepatitis C virus
(HCV) share a global presence and propensity to disproportionately affect marginalized …

Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities

HIM Boshoff, K Young, YM Ahn, VD Yadav… - ACS Infectious …, 2024 - ACS Publications
Linezolid is a drug with proven human antitubercular activity whose use is limited to highly
drug-resistant patients because of its toxicity. This toxicity is related to its mechanism of …

[HTML][HTML] Mutations and insights into the molecular mechanisms of resistance of Mycobacterium tuberculosis to first-line

NO Rossini, MVB Dias - Genetics and molecular biology, 2023 - SciELO Brasil
Genetically antimicrobial resistance in Mycobacterium tuberculosis is currently one of the
most important aspects of tuberculosis, considering that there are emerging resistant strains …

[HTML][HTML] Grade III severe QT prolongation in an Indian male on all-oral longer regimen for multidrug-resistant pulmonary tuberculosis: world's first case

S Yadav - Cureus, 2022 - ncbi.nlm.nih.gov
Antitubercular drugs are associated with several adverse drug reactions (ADRs). Some of
these ADRs are life-threatening and require immediate attention and hospital admission …

Phages for the treatment of Mycobacterium species

CJ Opperman, J Wojno, W Goosen, R Warren - Progress in Molecular …, 2023 - Elsevier
Highly drug-resistant strains are not uncommon among the Mycobacterium genus, with
patients requiring lengthy antibiotic treatment regimens with multiple drugs and harmful side …

Multidrug-resistant tuberculosis in Iran: a multicenter study

F Khelghati, FN Seilakhori, M Goudarzi… - … Archives for Chest …, 2024 - monaldi-archives.org
The worldwide incidence of multi-drug-resistant tuberculosis (MDR-TB) is rapidly increasing,
and it has emerged as a pressing public health issue in Iran. Nevertheless, there is a …

[HTML][HTML] Advancement in Reperfusion Injury Awareness and Mitigation

V Bhavsar, A Patel, S Padhiyar, TB Patel, V Prajapati - 2023 - intechopen.com
Understanding reperfusion damage, raising knowledge of its underlying processes, and
creating measures to lessen its negative consequences have all seen significant progress …