[HTML][HTML] PD-1/PD-L1 and DNA damage response in cancer

M Kciuk, D Kołat, Ż Kałuzińska-Kołat, M Gawrysiak… - Cells, 2023 - mdpi.com
The application of immunotherapy for cancer treatment is rapidly becoming more
widespread. Immunotherapeutic agents are frequently combined with various types of …

Regulatory T cells in gastric cancer: Key controllers from pathogenesis to therapy

I Negura, M Pavel-Tanasa, M Danciu - Cancer Treatment Reviews, 2023 - Elsevier
Gastric cancer (GC) is a highly aggressive malignancy that remains a significant contributor
to cancer-related mortality worldwide, despite a decline in incidence in recent years. Early …

[HTML][HTML] Advances and key focus areas in gastric cancer immunotherapy: A comprehensive scientometric and clinical trial review (1999-2023)

YN Li, B Xie, Y Zhang, MH He, Y Xing… - World Journal of …, 2023 - ncbi.nlm.nih.gov
BACKGROUND Gastric cancer (GC) is the sixth most common cancer and third leading
cause of cancer-related deaths worldwide. Current treatments mainly rely on surgery-and …

HERIZON-GEA-01: Zanidatamab+ chemo±tislelizumab for 1L treatment of HER2-positive gastroesophageal adenocarcinoma

J Tabernero, L Shen, E Elimova, G Ku, T Liu… - Future …, 2022 - Taylor & Francis
HER2-positive gastroesophageal adenocarcinomas (GEAs) are common cancers with high
mortality and the treatment options for advanced/metastatic disease are limited …

[HTML][HTML] HER2-positive gastric cancer: the role of immunotherapy and novel therapeutic strategies

A Pous, L Notario, C Hierro, L Layos… - International journal of …, 2023 - mdpi.com
Gastric cancer is an aggressive disease with increasing global incidence in recent years.
Human epidermal growth receptor 2 (HER2) is overexpressed in approximately 10–20% of …

[HTML][HTML] Recent progress and current challenges of immunotherapy in advanced/metastatic esophagogastric adenocarcinoma

M Moehler, A Högner, AD Wagner… - European Journal of …, 2022 - Elsevier
The new era of immunotherapy is successfully implemented in the treatment of
metastatic/locally advanced esophagogastric adenocarcinoma (EGAC), as it has been …

[HTML][HTML] HER2 inhibition in gastric Cancer—Novel therapeutic approaches for an established target

C Fong, I Chau - Cancers, 2022 - mdpi.com
Simple Summary The human epidermal growth factor receptor 2 (HER2) became the first
routinely targeted biomarker in the management of stomach cancers when the monoclonal …

Current state of the art: immunotherapy in esophageal cancer and gastroesophageal junction cancer

N Li, D Sohal - Cancer Immunology, Immunotherapy, 2023 - Springer
Esophageal cancers have a high mortality rate and limited treatment options especially in
the advanced/metastatic setting. Squamous cell carcinoma (SCC) and adenocarcinoma are …

[HTML][HTML] Predictive biomarkers and new developments of immunotherapy in gastric cancer: a 2023 update

Y Nie, W Zhao, L Lu, F Zhou - American Journal of Cancer …, 2023 - ncbi.nlm.nih.gov
Gastric cancer is an extremely common digestive tract tumor. The promotion and application
of standardized therapy, treatment scheme optimization, and development of new targeted …

[HTML][HTML] Determinants of survival with combined HER2 and PD-1 blockade in metastatic esophagogastric cancer

SB Maron, W Chatila, H Walch, JF Chou, N Ceglia… - Clinical Cancer …, 2023 - AACR
Purpose: We report updated clinical outcomes from a phase II study of pembrolizumab,
trastuzumab, and chemotherapy (PTC) in metastatic esophagogastric cancer in conjunction …