The conventional classification of known immune responses by specificity may need re-
evaluation. The immune system can be classified into two subsystems: the innate and …

T cells carry out the formidable task of identifying small numbers of foreign antigenic
peptides rapidly and specifically against a very noisy environmental background of …

A long-standing paradox in the study of T cell antigen recognition is that of the high
specificity–low affinity T cell receptor (TCR)–major histocompatibility complex peptide …

Summary T cell receptor (TCR-CD3) triggering involves both receptor clustering and
conformational changes at the cytoplasmic tails of the CD3 subunits. The mechanism by …

The T-cell antigen receptor (TCR) exists in monomeric and nanoclustered forms
independently of antigen binding. Although the clustering is involved in the regulation of T …

The activation of T cells mediated by the T cell antigen receptor (TCR) requires the
interaction of dozens of proteins, and its malfunction has pathological consequences. Our …

The CD3εγ heterodimer is essential for expression and function of the T cell receptor. The
crystal structure of the human CD3εγ heterodimer is described to 2.1-Å resolution …

The adaptive phase of the immune response begins with engagement on CD4+ helper T
cells of the T cell antigen receptor (TCR) 1 by its ligand, a small foreign peptide bound to a …

Despite compromised T cell antigen receptor (TCR) signaling, mice in which tyrosine 136 of
the adaptor linker for activation of T cells (LAT) was constitutively mutated (Lat Y136F mice) …

Despite the low affinity of the T‐cell antigen receptor (TCR) for its peptide/major
histocompatibility complex (pMHC) ligand, T cells are very sensitive to their antigens. This …