[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges
MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …
[HTML][HTML] The dual role of autophagy in cancer development and a therapeutic strategy for cancer by targeting autophagy
CW Yun, J Jeon, G Go, JH Lee, SH Lee - International journal of …, 2020 - mdpi.com
Autophagy is a delicate intracellular degradation process that occurs due to diverse stressful
conditions, including the accumulation of damaged proteins and organelles as well as …
conditions, including the accumulation of damaged proteins and organelles as well as …
Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer
N Li, X Zhang, J Zhou, W Li, X Shu, Y Wu… - Advanced Drug Delivery …, 2022 - Elsevier
A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …
Biosynthesis and cytotoxic effect of silymarin-functionalized selenium nanoparticles induced autophagy mediated cellular apoptosis via downregulation of PI3K/Akt …
X Mi, HS Choi, H Perumalsamy, R Shanmugam… - Phytomedicine, 2022 - Elsevier
Background Silymarin, a blend of flavonolignans isolated from plant Silybum marianum L.,
has long been used as an herbal medicine. Biogenic routes especially the plant-based …
has long been used as an herbal medicine. Biogenic routes especially the plant-based …
[HTML][HTML] Targeting EGFR/PI3K/AKT/mTOR signaling in hepatocellular carcinoma
J Bang, M Jun, S Lee, H Moon, SW Ro - Pharmaceutics, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) poses a significant global health concern, with its
incidence steadily increasing. The development of HCC is a multifaceted, multi-step process …
incidence steadily increasing. The development of HCC is a multifaceted, multi-step process …
[HTML][HTML] Anticancer potential of natural chalcones: in vitro and in vivo evidence
R Michalkova, L Mirossay, M Kello… - International Journal of …, 2023 - mdpi.com
There is no doubt that significant progress has been made in tumor therapy in the past
decades. However, the discovery of new molecules with potential antitumor properties still …
decades. However, the discovery of new molecules with potential antitumor properties still …
[HTML][HTML] Molecular mechanisms of antiproliferative effects of natural chalcones
R Michalkova, L Mirossay, M Gazdova, M Kello… - Cancers, 2021 - mdpi.com
Simple Summary Despite the important progress in cancer treatment in the past decades,
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …
Natural products targeting macroautophagy signaling in hepatocellular carcinoma therapy: Recent evidence and perspectives
Y Chen, X Tan, W Zhang, Y Li, X Deng… - Phytotherapy …, 2024 - Wiley Online Library
Hepatocellular carcinoma (HCC), presently the second leading cause of global cancer‐
related mortality, continues to pose significant challenges in the realm of medical oncology …
related mortality, continues to pose significant challenges in the realm of medical oncology …
[HTML][HTML] Licorice (Glycyrrhiza glabra L.)-derived phytochemicals target multiple signaling pathways to confer oncopreventive and oncotherapeutic effects
Cancer is a highly lethal disease, and its incidence has rapidly increased worldwide over
the past few decades. Although chemotherapeutics and surgery are widely used in clinical …
the past few decades. Although chemotherapeutics and surgery are widely used in clinical …
[HTML][HTML] Programmed cell death alterations mediated by synthetic indole chalcone resulted in cell cycle arrest, DNA damage, apoptosis and signaling pathway …
R Michalkova, M Kello, Z Kudlickova, M Gazdova… - Pharmaceutics, 2022 - mdpi.com
Although new chemotherapy significantly increased the survival of breast cancer (BC)
patients, the use of these drugs is often associated with serious toxicity. The discovery of …
patients, the use of these drugs is often associated with serious toxicity. The discovery of …