Nanoparticles in drug delivery: From history to therapeutic applications

O Afzal, ASA Altamimi, MS Nadeem, SI Alzarea… - Nanomaterials, 2022 - mdpi.com
Current research into the role of engineered nanoparticles in drug delivery systems (DDSs)
for medical purposes has developed numerous fascinating nanocarriers. This paper reviews …

Therapeutic potential of cannabis, cannabidiol, and cannabinoid-based pharmaceuticals

CA Legare, WM Raup-Konsavage, KE Vrana - Pharmacology, 2022 - karger.com
Background: There is a growing interest in the use of cannabis (and its extracts), as well as
CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes. While there is …

Engineering macrophage exosome disguised biodegradable nanoplatform for enhanced sonodynamic therapy of glioblastoma

T Wu, Y Liu, Y Cao, Z Liu - Advanced Materials, 2022 - Wiley Online Library
Sonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation
damage to normal tissues, and thus emerges as a promising cancer therapeutic modality for …

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

AR Pombo Antunes, I Scheyltjens, F Lodi… - Nature …, 2021 - nature.com
Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …

Effect of nivolumab vs bevacizumab in patients with recurrent glioblastoma: the CheckMate 143 phase 3 randomized clinical trial

DA Reardon, AA Brandes, A Omuro… - JAMA …, 2020 - jamanetwork.com
Importance Clinical outcomes for glioblastoma remain poor. Treatment with immune
checkpoint blockade has shown benefits in many cancer types. To our knowledge, data from …

Remote neuronal activity drives glioma progression through SEMA4F

E Huang-Hobbs, YT Cheng, Y Ko, E Luna-Figueroa… - Nature, 2023 - nature.com
The tumour microenvironment plays an essential role in malignancy, and neurons have
emerged as a key component of the tumour microenvironment that promotes tumourigenesis …

Highly sensitive detection of malignant glioma cells using metamaterial-inspired THz biosensor based on electromagnetically induced transparency

J Zhang, N Mu, L Liu, J Xie, H Feng, J Yao… - Biosensors and …, 2021 - Elsevier
Metamaterial-inspired biosensors have been extensively studied recently years for fast and
low-cost THz detection. However, only the variation of the resonance frequency has been …

Application of proteomics in cancer: recent trends and approaches for biomarkers discovery

YW Kwon, HS Jo, S Bae, Y Seo, P Song, M Song… - Frontiers in …, 2021 - frontiersin.org
Proteomics has become an important field in molecular sciences, as it provides valuable
information on the identity, expression levels, and modification of proteins. For example …

Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

G Agliardi, AR Liuzzi, A Hotblack, D De Feo… - Nature …, 2021 - nature.com
Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain
cancer, for which effective therapies are urgently needed. Chimeric antigen receptor (CAR) …

Longer-term (≥ 2 years) survival in patients with glioblastoma in population-based studies pre-and post-2005: a systematic review and meta-analysis

MTC Poon, CLM Sudlow, JD Figueroa, PM Brennan - Scientific reports, 2020 - nature.com
Translation of survival benefits observed in glioblastoma clinical trials to populations and to
longer-term survival remains uncertain. We aimed to assess if≥ 2-year survival has …