[HTML][HTML] Therapeutic strategies of three-dimensional stem cell spheroids and organoids for tissue repair and regeneration
Abstract Three-dimensional (3D) stem cell culture systems have attracted considerable
attention as a way to better mimic the complex interactions between individual cells and the …
attention as a way to better mimic the complex interactions between individual cells and the …
Cell culture in microfluidic droplets
Cell manipulation in droplets has emerged as one of the great successes of microfluidic
technologies, with the development of single-cell screening. However, the droplet format has …
technologies, with the development of single-cell screening. However, the droplet format has …
Organs-on-a-chip: a fast track for engineered human tissues in drug development
K Ronaldson-Bouchard, G Vunjak-Novakovic - Cell stem cell, 2018 - cell.com
Organs-on-a-chip (OOCs) are miniature tissues and organs grown in vitro that enable
modeling of human physiology and disease. The technology has emerged from converging …
modeling of human physiology and disease. The technology has emerged from converging …
Advances in Spheroids and Organoids on a Chip
Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …
medicine and drug screening. They replicate the structural and functional characteristics of …
Functional precision oncology using patient-derived assays: bridging genotype and phenotype
AWJ van Renterghem, J van de Haar… - Nature Reviews Clinical …, 2023 - nature.com
Genomics-based precision medicine has revolutionized oncology but also has inherent
limitations. Functional precision oncology is emerging as a complementary approach that …
limitations. Functional precision oncology is emerging as a complementary approach that …
Recent advances in droplet microfluidics
Y Ding, PD Howes, AJ deMello - Analytical chemistry, 2019 - ACS Publications
Prominent within this technology set are droplet-based microfluidic systems, 3 in which
passive microfluidic structures are used to rapidly generate and manipulate subnanoliter …
passive microfluidic structures are used to rapidly generate and manipulate subnanoliter …
Developmentally engineered callus organoid bioassemblies exhibit predictive in vivo long bone healing
Clinical translation of cell‐based products is hampered by their limited predictive in vivo
performance. To overcome this hurdle, engineering strategies advocate to fabricate tissue …
performance. To overcome this hurdle, engineering strategies advocate to fabricate tissue …
Organ-on-chip models of cancer metastasis for future personalized medicine: From chip to the patient
Most cancer patients do not die from the primary tumor but from its metastasis. Current in
vitro and in vivo cancer models are incapable of satisfactorily predicting the outcome of …
vitro and in vivo cancer models are incapable of satisfactorily predicting the outcome of …
Recent methods of droplet microfluidics and their applications in spheroids and organoids
Y Wang, M Liu, Y Zhang, H Liu, L Han - Lab on a Chip, 2023 - pubs.rsc.org
Droplet microfluidic techniques have long been known as a high-throughput approach for
cell manipulation. The capacity to compartmentalize cells into picolitre droplets in …
cell manipulation. The capacity to compartmentalize cells into picolitre droplets in …
Engineered microsystems for spheroid and organoid studies
Abstract 3D in vitro model systems such as spheroids and organoids provide an opportunity
to extend the physiological understanding using recapitulated tissues that mimic …
to extend the physiological understanding using recapitulated tissues that mimic …