Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …

Social behaviors are among the most important motivated behaviors. How dopamine (DA),
a" reward" signal, releases during social behaviors has been a topic of interest for decades …

Rhythmic neural network activity has been broadly linked to behavior. However, it is unclear
how membrane potentials of individual neurons track behavioral rhythms, even though …

The basal ganglia play an important role in decision making and selection of action primarily
based on input from cortex, thalamus, and the dopamine system. Their main input structure …

Following almost three decades of genetic-based research related to identifying and
characterizing addiction-related Reward Deficiency Syndrome (RDS), a paradigm shift is …

Perturbations in striatal dopamine (DA) homeostasis might underlie the behavioral and
pathobiological consequences of METH use disorder in humans. To identify potential …

The caudal part of the striatum, also named the tail of the striatum (TS), defines a fourth
striatal domain. Determining whether rewarding, aversive and salient stimuli regulate the …

The dopaminergic system undergoes major reorganization during development, a period
especially vulnerable to mental disorders. Forebrain neurons expressing dopamine 1 and 2 …

Since the discovery of striatal neurons expressing dopamine-synthesizing enzymes,
researchers have attempted to identify their phenotype and functional significance. In this …

Background Corticostriatal circuits, particularly the dorsomedial striatum (DMS) and lateral
orbitofrontal cortex, are critical for navigating reversal learning under probabilistic …